摘要
Abstract
Objective To compare the clinical effects of aripiprazole and risperidone in the treatment of schizo‐phrenia and their influence on patients′cognitive function .Methods 92 cases of schizophrenia meeting the inclusion criteria were divided into the risperidone group (RG ,n=43) and the aripiprazole group (AG ,n=49) according to the therapeutic schemes .The RG group was treated with risperidone and the AG group with aripiprazole for 8 weeks . Then ,the clinical efficacy was evaluated by adopting the positive and negative symptoms scale (PANSS ) ,and the cognitive function by the Mini‐Mental State Examination (MMSE) ,Wisconsin Card Sorting Test (WCST ) and the Personal and Social Performance Scale (PSP) .Results The total effective rate was 91 .8% in the RG group and 88 .4% in the AG group without statistical difference between the two groups (P> 0 .05) .After treatments ,the scores of positive symptoms ,negative symptoms and psychiatric pathology and the total score for PANSS in the RG group were (11 .2 ± 4 .2)points ,(12 .7 ± 4 .8)points ,(24 .2 ± 9 .5) points and (48 .1 ± 13 .1) points ,which in the AG . group were (11 .0 ± 3 .8) points ,(12 .3 ± 5 .1) points ,(23 .7 ± 7 .7) points and (47 .0 ± 14 .7) points ,all were signifi‐cantly decreased compared with before treatment ,the differences were statistically significant (P< 0 .05) ,but the differences after treatment between the two groups were not statistically significant (P>0 .05) .As to the cognitive function ,the scores of MMSE and PSP after treatment were (23 .9 ± 3 .7) points and (64 .7 ± 8 .2) points in the RG group and (26 .1 ± 2 .8) points and (75 .4 ± 7 .6) points in the AG group ,the scores of MMSE and PSP after treat‐ment in the two groups were significantly increased ,the differences were statistically significant (P<0 .01) ,the scores of MMSE and PSP after treatment in the AG were significantly higher than those in the RG group (P<0 .01) .Dur‐ing treatment ,no severe adverse reactions occurred in the two groups ,and the incidence rate of adverse reactions had no statistically significant difference between the two groups (P> 0 .05) .Conclusion Aripiprazole is an effective drug for the treatment of schizophrenia .Its clinical effect is same to that of risperidone ,but is superior to risperidone in improving patient′s cognitive function and has mild adverse reactions ,which is worthy to be further researched in clinic .关键词
阿立哌唑/利培酮/精神分裂症/认知功能Key words
aripiprazole/risperidone/schizophrenia/cognitive function
