检验医学与临床Issue(21)：3224-3226,3.DOI:10.3969/j.issn.1672-9455.2015.21.036
床旁快速联合测定肌钙蛋白 I、肌酸激酶同工酶和肌红蛋白诊断急性心肌梗死的临床价值
Clinical value of bedside rapid combined detection of cTnI,CK-MB and MB for early diagnosis of acute myocardial in-farction
周艳丽 1章静 1王淑春 1张建军 1宋杨英1
作者信息
摘要
Abstract
Objective To investigate and analyze the clinical application value of bedside rapid combined detec‐tion of cardiac troponin Ⅰ(cTnI) ,creatine kinase(CK‐MB) and myohemoglobin(MB) for the diagnosis of acute myo‐cardial infarction(AMI) .Methods 138 emergency cases with chest pain onset less than 3 h in our hospital from Jan‐uary 2013 to August 2014 were selected as the research subjects and divided into the AMI group (observation group) and non‐AMI group (control group) according to the diagnostic criteria of AMI .The Judkins method was adopted to conduct the coronary arteriongraphy via right femoral artery with 6 F coronary arteriography catheter .The diagnosed AMI patients were treated by adopting percutaneous coronary intervention (PCI) .The timing extraction of venous blood samples was performed for detecting the serum levels of cTnI ,CK‐MB and MB .Results The detection results at various time periods in the two groups showed that serum cTnI ,CK‐MB and MB levels in the observation group were significantly higher than those in the control group (P<0 .05) .The sensitivity and the specificity in the com‐bined detection of serum cTnI ,CK‐MB and MB levels for diagnosing AMI were 97 .2% and 88 .3% respectively , which were significantly higher than 86 .8% ,81 .3% ,84 .2% and 78 .6% ,74 .6% ,72 .5% in the single detection of these 3 indicators respectively ,the differences were statistically significant (P<0 .05) .Conclusion The bedside rapid combined detection of cTnI ,CK‐MB and MB can significantly increase the sensitivity and specificity for diagnosing AMI ,has the results consistent to that of the coronary angiography and can be promoted and applied in clinic .关键词
急性心肌梗死/肌钙蛋白I/肌酸激酶同工酶/肌红蛋白Key words
acute myocardial infarction/cardiac troponin/creatine kinase isoenzyme/myohemoglobin引用本文复制引用
周艳丽,章静,王淑春,张建军,宋杨英..床旁快速联合测定肌钙蛋白 I、肌酸激酶同工酶和肌红蛋白诊断急性心肌梗死的临床价值[J].检验医学与临床,2015,(21):3224-3226,3.
