检验医学与临床Issue(22)：3314-3317,4.DOI:10.3969/j.issn.1672-9455.2015.22.009
H PV L1壳蛋白与 P16蛋白联合检测在宫颈癌前病变中的临床意义
Clinical significance of combined detection of HPV L1 capsid protein and P16 protein in cervical precancerous lesion
摘要
Abstract
Objective To evaluate the clinical significance of the combination detection of human papillomavir‐us(HPV) L1 capsid protein and p16 protein in the diagnosis of cervical precancerous lesion and its predictive value to disease outcome .Methods 208 cases of abnormal in thinprep cytologic test and high risk(HR)‐HPV positive were performed the cervical biopsy and grouped according to the histopathologic test .Meanwhile ,these cases were detected the HPV L1 capsid protein and the p16 protein and then divided into 4 groups according to the expression situation of these two kinds of antibody .Among them ,155 followed up cases were performed the analysis of HPV negative con‐version .Results The expression of L1 and P16 was different among different grades of cervical tissues ,the positive rate of L1 in the cervical intraepithelial neoplasia(CIN)Ⅰ group was higher than that of other CIN groups(P<0 .01) and the positive rate of P16 in the ≥CINⅢ group was higher than that in the other 3 groups(P<0 .01) .Among the follow‐up cases ,the negative conversion rate in the HPV L1(+ )/P16(-) was higher ,especially which in the CINⅠgroup was higher than other groups(P<0 .05) .Conclusion The combined detection of HPV L1 capsid protein and P16 protein can be used as an effective indicator in the diagnosis and prediction of cervical lesions .关键词
宫颈癌前病变/HPV L1壳蛋白/P16Key words
cervical intraepithelial neoplasia/HPV L1 capsid protein/P16 protein引用本文复制引用
罗阳刚,吕玉宇..H PV L1壳蛋白与 P16蛋白联合检测在宫颈癌前病变中的临床意义[J].检验医学与临床,2015,(22):3314-3317,4.基金项目
重庆市卫生和计划生育委员会医学科研资助项目（20142170）；重庆市南岸区卫生和计划生育委员会医学科研资助项目。 （）
