检验医学与临床Issue(22)：3337-3338,3341,3.DOI:10.3969/j.issn.1672-9455.2015.22.017
血浆1，3-β-D 葡聚糖对卡氏肺孢子菌肺炎的诊断价值
Clinical value of plasma 1,3-β-D glucan in diagnosis of Pneumocystis carinii pneumonia
伊洁 1郑力胜 1窦亚玲1
作者信息
- 1. 中国医学科学院北京协和医院检验科，北京 100730
- 折叠
摘要
Abstract
Objective To explore the clinical value of plasma 1 ,3‐β‐D glucan in the diagnosis of Pneumocystis carinii pneumonia(PCP) .Methods 50 patients with PCP ,50 patients with Pneumocystis carinii(PC) colonization and contemporaneous 50 patients without PC colonization were recruited as the study subjects and tested for plasma 1 ,3‐β‐D glucan(BG) .Results Median plasma BG in the PCP patients was 698 .5 pg/mL [interquartile range(IQR):184 .4-1 256 .0 pg/mL] ,which was higher than 66 .5 pg/mL(IQR:50 .0-91 .0 pg/mL) in the PC colonization and 135 .9 pg/mL(IQR:54 .0-556 .3 pg/mL) in the PC noncolonization patients ,respectively .The average level of plas‐ma BG in the PCP patients was (1 022 .8 ± 982 .6)pg/mL ,which was also higher than (74 .7 ± 33 .6)pg/mL and (562 .7 ± 934 .9)pg/mL in the PC colonization and PC noncolonization patients ,respectively .The difference of the av‐erage levels among three groups was statistically significant(P< 0 .05) .With 151 .5 pg/mL as the positive critical value ,the sensitivity ,specificity ,positive and negative predictive values of plasma BG for diagnosing PCP were 96 .0% ,74 .0% ,64 .9% and 97 .4% respectively .With plasma BG as the diagnostic method of PCP ,the area under the curve(AUC) of receiver operating characteristic(ROC) curve was 0 .89 .Conclusion The plasma BG can be used as an early diagnostic indicator of PCP ,which also can differentiate PCP from PC colonization .关键词
1,3-β-D葡聚糖/卡氏肺孢子菌肺炎/卡氏肺孢子菌定植Key words
1 ,3-β-D glucan/Pneumocystis carinii pneumonia/Pneumocystis carinii colonization引用本文复制引用
伊洁,郑力胜,窦亚玲..血浆1，3-β-D 葡聚糖对卡氏肺孢子菌肺炎的诊断价值[J].检验医学与临床,2015,(22):3337-3338,3341,3.
