检验医学与临床Issue(22)：3339-3341,3.DOI:10.3969/j.issn.1672-9455.2015.22.018
地西他滨联合 CAG 方案治疗骨髓增生异常综合征的疗效观察
Observation on curative effect of decitabine combined with CAG scheme in treatment of myelodysplastic syndrome
关琦 1于果 1张海军1
作者信息
- 1. 内蒙古自治区林业总医院血液肿瘤科，内蒙古牙克石 022150
- 折叠
摘要
Abstract
Objective To observe the clinical effect of decitabine combined with CAG scheme in the treatment of myelodysplastic syndrome .Methods 73 cases of myelodysplastic syndrome in our hospital from February 2007 to January 2012 were chosen and randomly divided into the control group(36 cases) and the treatment group(37 cases) . The control group was treated with the CAG regimen ,while the treatment group was given the CAG scheme com‐bined with decitabine treatment .The changes of vascular endothelial growth factor(VEGF) before treatment and after treatment ,total effective rate ,survival time and adverse reactions were compared between the two groups .Results The VEGF levels on 1 ,3 ,7 ,14 d after treatment in the two group were all significantly lower than those before thera‐py(P<0 .05) ,moreover the decrease in the treatment group was more significant than the control group ,the differ‐ence was statistically significant(P<0 .05);the total effective rates of the treatment group and the control group were 75 .6% and 61 .1% respectively ,the treatment group was higher than the control group with statistical difference(P<0 .05);the overall survival time and disease‐free survival time in the treatment group were significantly better than those in the control group ,the differences were statistically significant(P<0 .05);the incidence rate of adverse reac‐tions in the treatment group was 67 .2% ,which was significantly lower than 77 .8% in the control group ,the differ‐ences were statistically significant(P<0 .05) .Conclusion Decitabine combined with CAG scheme in treating myelo‐dysplastic syndrome has long survival time ,obvious effect and is worthy of promotion .关键词
骨髓增生异常综合征/地西他滨/CAG方案Key words
decitabine/CAG scheme/myelodysplastic syndrome引用本文复制引用
关琦,于果,张海军..地西他滨联合 CAG 方案治疗骨髓增生异常综合征的疗效观察[J].检验医学与临床,2015,(22):3339-3341,3.
