检验医学与临床Issue(22)：3373-3375,3.DOI:10.3969/j.issn.1672-9455.2015.22.031
首发精神分裂症患者外周血Reelin基因甲基化检测
Detection of peripheral blood Reelin gene methylation in patients with first-episode schizophrenia
杨悦 1宋志伟 1韩丽 1马学华 1李秋平 1冯磊光1
作者信息
- 1. 哈尔滨医科大学附属第一医院检验科，哈尔滨 150001
- 折叠
摘要
Abstract
Objective To study the relationship between DNA methylation with schizophrenia by investigating the DNA methylation status of peripheral blood Reelin gene promoter in the patients with schizophrenia .Methods The Reelin gene promoter DNA methylation was measured in 76 patients with schizophrenia(patients group) and 60 healthy controls(healthy control group) by adopting methylation‐specific PCR .Results The methylation positive rate in the patients group was 78 .95% (60 cases) ,which in the healthy control group was 35% (21 cases) ,the differ‐ence was statistically significant(χ2 =4 .971 ,P=0 .026);the Logistic regression analysis showed that the Reelin gene methylation was correlated with schizophrenia(OR=13 .084 ,95% CI:5 .079-26 .308) .Conclusion The Reelin gene promoter DNA methylation is associated with schizophrenia ,and the peripheral blood Reelin gene promoter DNA methylation presents the supermethylation status in the patients with schizophrenia .Reelin gene DNA methylation is the risk factor for schizophrenia .关键词
精神分裂症/Reelin基因/DNA甲基化Key words
schizophrenia/Reelin gene/DNA methylation引用本文复制引用
杨悦,宋志伟,韩丽,马学华,李秋平,冯磊光..首发精神分裂症患者外周血Reelin基因甲基化检测[J].检验医学与临床,2015,(22):3373-3375,3.
