摘要
Abstract
Objective To investigate the efficacy of thalidomide in treating systemic lupus erythematosus (SLE) by comparing the clinical effects between thalidomide and prednisone combined with cyclophosphamide for treating SLE .Methods 56 patients with SLE in the rheumatism and immunology department of our hospital were se‐lected and randomly divided into two groups .28 cases in the control group were treated with the conventional therapy of glucocorticoid combined with cyclophosphamide ,while 28 cases in the experimental group were given only the tha‐lidomide treatment .After treatment ,the skin rash situation ,blood routine ,renal function and immune indexes were compared between before and after treatment in the two groups .Results (1)After the treatment ,the skin rashes in the two groups were disappeared ,but the effect in the experimental group was significantly superior to the control group ,moreover the skin rash disappearance time in the experimental group was obviously decreased compared with the control group ,the differences were statistically significant(P<0 .05) .(2) The counts of white blood cell(WBC) , platelets and lymphocytes and hemoglobin level after treatment in the experimental group were significantly increased compared with the control group ,the differences were statistically significant(P<0 .05) .(3)The renal function after treatment in the two groups was improved ,moreover the urinary protein level in the experimental group was de‐creased compared with the control group and the serum albumin level was increased obviously ,the differences were statistically significant(P<0 .05) .(4) The titer of ANA and anti‐ds‐DNA antibody level after treatment in the ex‐perimental group were decreased significantly ,the differences were statistically significant(P<0 .05) .Conclusion Thalidomide can obviously improve the skin rash situation in SLE ,repairs the renal injury ,corrects anemia and other blood diseases ,repairs the autoimmune tolerance by effectively removing immunoreactive cells ,the treatment effect is remarkable ,which is worth the clinical promotion .关键词
系统性红斑狼疮/沙利度胺/环磷酰胺Key words
systemic erythematosus lupus/erythematosus/thalidomide/cyclophosphamide
