检验医学与临床Issue(23)：3458-3460,3.DOI:10.3969/j.issn.1672-9455.2015.23.004
3项指标联合检测在冠状动脉粥样硬化合并慢性心力衰竭患者中的意义
Significance of combined detection of three indicators in coronary atherosclerosis patients with chronic heart failure
摘要
Abstract
Objective To investigate the clinical significance of the detection of serum lipid ,lipoprotein‐α [Lp (α)] ,uric acid (UA) ,β2‐microglobulinandhigh (β2‐MG) and high sensitivity C‐reactive protein (hs‐CRP) in coronary atherosclerosis patients with chronic heart failure .Methods From January 2014 to December 2014 ,268 cases of coro‐nary atherosclerosis patients with chronic heart failure and 30 cases of coronary atherosclerosis patients without heart failure were collected in Renmin Hospital of Wuhan University .The levels of serum lipid ,Lp(α) ,UA ,β2‐MG and hs‐CRP were detected ,and the differences of the indicators between coronary atherosclerosis patients with different car‐diac functional grades .Results Among coronary atherosclerosis patients with different cardiac functional grades , there was no differences of serum liquid and Lp(α) levels (P> 0 .05) .The levels of UA ,β2‐MG and hs‐CRP increased with the cardiac functional grade (F= 3 .841 ,10 .241 and 4 .065 ,P< 0 .05) .The pairwise comparison of UA ,β2‐MG and hs‐CRP showed that β2‐MG and hs‐CRP levels of patients with cardiac functional grade Ⅱ were significantly higher than those of patients with cardiac functional grade Ⅰ (t= - 3 .358 ,- 3 .513 ,P< 0 .05) ;patients with cardiac functional grade Ⅲ had significantly higherβ2‐MG and hs‐CRP levels than patients with cardiac functional grade Ⅱ(t= - 5 .298 ,- 4 .666 ,P< 0 .05) ;and patients with cardiac functional grade Ⅳ had significantly higher UA ,β2‐MG and hs‐CRP levels than patients with cardiac functional grade Ⅲ (t= - 2 .777 ,- 4 .386 ,- 2 .222 ,P< 0 .05) .Pearson correlation analysis showed that β2‐MG was negatively correlated with TG (r = - 0 .534 ,P< 0 .05) ,hs‐CRP was pos‐itively correlated with TC ,TG ,LDL‐C (r= 0 .790 ,0 .608 ,0 .753 ,P< 0 .05) in patients with cardiac functional gradeⅠ ;β2‐MG was positively correlated with UA and hs‐CRP (r= 0 .409 and 0 .420 ,P< 0 .05) in patients with cardiac functional grade Ⅱ ;β2‐MG was negatively correlated with HDL‐C (r = - 0 .302 ,P< 0 .05) ,and positively correlated with UA (r= 0 .388 ,P < 0 .05) in patients with cardiac functional grade Ⅲ ;β2‐MG was positively correlated with TG and hs‐CRP (r= 0 .623 ,0 .502 ,P< 0 .05) ,and hs‐CRP was negatively correlated with HDL‐C (r = - 0 .543 ,P<0 .05) in patients with cardiac functional grade Ⅳ .Conclusion Combined detection of serum UA ,β2‐MG and hs‐CRP can dynamically monitor the heart function of patients with coronary atherosclerosis and provide a reasonable refer‐ence for the treatment and prognosis .关键词
尿酸/β2-微球蛋白/超敏 C 反应蛋白/冠状动脉粥样硬化/慢性心力衰竭Key words
uric acid/β2-microglobulinandhigh/high sensitivity C-reactive protein/coronary atheroscle-rosis/chronic heart failure引用本文复制引用
周方元,李艳,戴雯,赵锐,许淑文..3项指标联合检测在冠状动脉粥样硬化合并慢性心力衰竭患者中的意义[J].检验医学与临床,2015,(23):3458-3460,3.基金项目
国家重点临床专科建设项目［财社（2010）305号］。 （）
