检验医学与临床Issue(23)：3477-3478,3481,3.DOI:10.3969/j.issn.1672-9455.2015.23.011
宝安区不同年龄健康成人血浆 D-二聚体生物参考区间的建立
Establishment of biological reference intervals of plasma D-dimer for healthy adults of different ages in Bao′an District
摘要
Abstract
Objective To establish the biological reference intervals of plasma D‐dimer for healthy adults of different ages in Bao′an District ,so as to provide more scientific and valuable reference for diagnosis and treatment in clinic .Methods 1 156 healthy adults of different ages were selected in Department of Medical Examination ,Songgang People′s Hospital of Bao′an District ,from June 2014 to January 2015 ,there were 417 males and 739 females among which .According to their ages ,these healthy adults were divided into three groups :18 - 50 years old group ,> 50 -60 years old group and > 60 years old group .Plasma D‐dimer was detected by immune turbidimetric method on Sys‐mex CA1500 automatic blood coagulation analyzer .SPSS19 .0 software was used for the statistic analysis of the re‐sults .The unilateral upper limit of D‐dimer reference interval was represented by percentile (P95) ,since the detection results of D‐dimer was skewed distribution .The appropriate biological reference intervals were determined ,and the differences of D‐dimer levels among adults of different ages and different genders were analyzed and compared . Results In the same age group ,there was no significantly difference of the D‐dimer level between males and females (t= 0 .372 - 1 .092 ,P> 0 .05) .There was no significant difference of the D‐dimer level between 18 - 50 years old group and > 50 - 60 years old group (t= 0 .954 ,P > 0 .05) .The D‐dimer level of > 60 years old group was signifi‐cantly different from another two age groups (t= 5 .972 ,P< 0 .05) .The reference intervals of healthy adults of 18 -60 years old and > 60 years old were 0 - 225 and 0 - 297 mg/L ,respectively .Conclusion The plasma D‐dimer level was age‐related ,which was not associated with gender .The D‐dimer level inceased with age .The appropriate biologi‐cal reference intervals of D‐dimer should be established ,when the detection objects ,instruments and detection rea‐gents were different .关键词
健康成人/血浆 D-二聚体/免疫比浊法/参考区间Key words
healthy adults/plasma D-dimer/immune turbidimetry/reference interval引用本文复制引用
姚伟,房笃智..宝安区不同年龄健康成人血浆 D-二聚体生物参考区间的建立[J].检验医学与临床,2015,(23):3477-3478,3481,3.基金项目
广东省深圳市宝安区科技局基金资助项目（2014051）。 （）
