摘要
Abstract
Objective To investigate the mechanism and influence of hyperuricemia to vascular complications in type 2 diabetes .Methods 182 cases of patients with type 2 diabetes in Hainan Agricultural Reclamation General Hospital were selected from June 2013 to June 2014 ,and divided into hyperuricemia group ,hypouricemia group and normal uric acid group ,according to the patients′ uric acid levels .The biochemical indicator levels and the complica‐tion incidences of three groups were observed and compared .Results The levels of TC ,TG ,LDL‐C and BMI of hy‐peruricemia group and hypouricemia group were significantly higher than those of normal uric acid group (P< 0 .05) . And the levels of TC ,TG ,LDL‐C and BMI of hyperuricemia group were significantly higher than those of hypourice‐mia group (P< 0 .05) .The levels of HDL‐C of hyperuricemia group and hypouricemia group were significantly lower than that of normal uric acid group (P < 0 .05) .And the level of HDL‐C of hyperuricemia group was significantly lower than that of hypouricemia group (P< 0 .05) .There was no significant difference of blood pressure and fasting blood glucose among three groups (P > 0 .05) .The incidences of vascular complications ,such as microvascular le‐sions ,macroangiopathy ,neuropathy ,cerebrovascular disease and coronary heart disease ,were significantly higher in hyperuricemia group than in hypouricemia group and normal uric acid group (P < 0 .05) ,however ,there was no sig‐nificant difference between hypouricemia group and normal uric acid group (P> 0 .05) .Conclusion Hyperuricemia is related with the corpulence and the abnormal lipid metabolism of patients with type 2 diabetes .Hyperuricemia can in‐crease the opportunity of metabolic disturbance in patients with type 2 diabetes ,which can promote the development and progression of its complications .关键词
高尿酸血症/2 型糖尿病/并发症/作用机制Key words
hyperuricemia/type 2 diabetes mellitus/complications/mechanism
