临床骨科杂志Issue(5)：577-580,4.DOI:10.3969/j.issn.1008-0287.2015.05.028
骨未分化高级别多形性肉瘤的治疗探讨
Treatment of undifferentiated high grade pleomorphic sarcoma of bone
摘要
Abstract
Objective To investigate the clinical characteristic, treatment and prognosis of undifferentiated high grade pleomorphic sarcoma of bone( BUPS) . Methods Seven cases of BUPS were analyzed retrospectively, including sites of tumor, image findings, pathology, surgical staging of tumor, treatment and results of follow-up, and the related lit-erature was reviewed. The preoperative traditional X-ray, CT, MRI, ECT and PET/CT were made. All cases were performed operation when BUPS was confirmed by puncturing biopsy or open biopsy. Results Tumors involved in distal femur in 2 cases, proximal femur in 3 cases, the proximal tibia and ilium each in 1 case. Radiologic findings of BUPS were nonspecific, mainly with a patchy or motheaten pattern of bone destruction. There were 2 cases in stage ofⅡA, 4 ⅡB and 1 Ⅲ. Hip disarticulation was performed in 3 cases, limb salvage was performed in 4 cases, and the chemotherapy was performed in all cases. The time of follow-up was 12~102 (45 ± 30) months, 3 cases developed distant metastasis and all of them with pathologic fracture, 2 cases died of lung metastasis two years after operation, the rest 4 cases were disease-free survival. Conclusions Surgical treatment is the primary method for BUPS and standard chemotherapy can improve survival rate. Pathologic fracture is associated with a poor prognosis.关键词
骨未分化高级别多形性肉瘤/骨肿瘤/外科学/保肢术/化疗/预后Key words
undifferentiated high grade pleomorphic sarcoma of bone/bone neoplasms/surgery/limb salvage/chem-otherapy/prognosis分类
医药卫生引用本文复制引用
吴志圣,李菊明,韦永中..骨未分化高级别多形性肉瘤的治疗探讨[J].临床骨科杂志,2015,(5):577-580,4.基金项目
江苏省卫生厅面上项目(编号:H201405) （编号:H201405）
