临床小儿外科杂志Issue(5)：388-390,410,4.DOI:10.3969/j.issn.1671-6353.2015.05.011
DKK 1在儿童神经母细胞瘤组织中的表达及临床意义
Expression and clinical significance of DKK - 1 in neuroblastoma tissues
摘要
Abstract
Objetive To investigate the expression of DKK—1 in pediatric neuroblastoma(NB)tissues. Methods The expressions of DKK—1 in 38 cases of pediatric NB tissues,12 cases of pediatric gangliocytoma tissues and 11 cases of pediatric normal adrenal tissues were detected by immunohistochemical staining. Re-sults DKK—1 protein was localized in the cell membrane and cytoplasm.DKK —1 showed strong positive ex-pression in normal adrenal tissues,weakly positive expression in gangliocytoma tissues and negative expression in NB tissues,the difference was statistically significant(P <0.001 ).The expression differences between three different groups were statistically significant (F =187.257,P <0.001 ).Conclusions The expression of DKK—1 in NB tissues was lower than that of gangliocytoma tissues and normal adrenal tissues,which suggests that DKK—1 may play as a potential molecular marker for early diagnosis and prognosis monitoring in NB.关键词
神经母细胞瘤/基因表达/预后/儿童Key words
Neuroblastoma/Gene expression/Prognosis/Child引用本文复制引用
张蛟,刘秋亮,高敬尧,汪琪,王家祥..DKK 1在儿童神经母细胞瘤组织中的表达及临床意义[J].临床小儿外科杂志,2015,(5):388-390,410,4.基金项目
国家自然科学青年基金项目，项目名称DKK-1在神经母细胞瘤分化调控中的作用及其分子机制研究，编号81502187） （）
