临床与实验病理学杂志Issue(10)：1099-1101,1106,4.DOI:10.13315/j.cnki.cjcep.2015.10.005
食管组织中Cx43和E-cad的表达及其相关性分析
Expression and correlation of Cx43 and E-cad in esophageal carcinoma
邸永辉 1苗杰2
作者信息
- 1. 河北省邢台市人民医院 胸外科，邢台 054000
- 2. 河北省邢台市人民医院 病理科，邢台 054000
- 折叠
摘要
Abstract
Purpose To investigate the expression of the Cx43 and E-cad protein in esophageal carcinoma and normal esophageal tis-sue and to discuss their relationship. Methods SP immunohistochemical and Western blot analysis were used to detect the expression of Cx43 and E-cad in esophageal carcinoma and normal esophageal tissue. The relation between their expression and esophageal carci-noma was investigated. Results Immunohistochemical assay and Western blot analysis showed the expression levels of Cx43 and E-cad in esophageal carcinoma were significantly lower than that in normal esophageal tissue. The expression of Cx43 had correlation with lymph node metastasis. The expression of E-cad had correlation with degrees of pathological differentiation. There was a positive rela-tionship between the expression of Cx43 and E-cad in same sample. Conclusion Expression of Cx43 and E-cad protein is low in e-sophageal carcinoma, which can be helpful in the prediction of the biological behavior and prognosis of esophageal carcinoma.关键词
食管肿瘤/Cx43/E-cad/免疫组织化学/Western blotKey words
esophageal neoplasms/Cx43/E-cad/immunohistochemistry/Western blot分类
医药卫生引用本文复制引用
邸永辉,苗杰..食管组织中Cx43和E-cad的表达及其相关性分析[J].临床与实验病理学杂志,2015,(10):1099-1101,1106,4.
