河南科技大学学报（医学版）2015，Vol.33Issue(3)：166-168,3.
正交试验设计优化纳米骨架型辛伐他汀固体制剂
Formulation Optimization for Novel Nano-matrix Solid Drug Delivery System of Simvastatin by OrthogonaI Experiment Design
摘要
Abstract
Objective In order to increase the dissolution of simvastatin in vitro, a novel nano-matrix solid drug delivery system of simvastatin was prepared and the formulation was optimized. Methods The formulations were optimized by orthogonal experimental design, the ratio of colloid to drug(A), the ratio of polymer to drug( B) , types of colloid( C) and polymer( D) as the four factors and the three levels settled as 1:1, 1:3, 1:5 for A and B, A200, A300, A200+A300 for C, PVP, Eudragit L100, Eudragit L100-55 for D, the dissolution of simvastatin in vitro in the medium of pH 6. 8 phosphalated buffer (0. 3 % SDS) as the evaluation index. Results The optimized formulation was as follow:drug:A200+A300:PVP=1:3:3. The dissolution of simvastatin in the optimized formulation was the best. Conclusion Compared with the tablet ( shujiangzhi? ) , nano-matrix drug delivery system of simvastatin prepared according to the optimized formulation could significantly increase the drug dissolution in vitro.关键词
辛伐他汀/纳米骨架/正交试验设计/溶出度Key words
simvastabin/nano-matrix/orthogonal experimental design/dissolution in vitro分类
医药卫生引用本文复制引用
王永涵,师亚芳,刘芳芳,孟夏,吴菁,和素娜..正交试验设计优化纳米骨架型辛伐他汀固体制剂[J].河南科技大学学报（医学版）,2015,33(3):166-168,3.基金项目
河南科技大学青年科学基金(2013QN041)河南科技大学大学生训练计划(2014212) （2013QN041）
