泸州医学院学报Issue(2)：148-151,4.
药物性肝损害文献分析
Analysis of the literature on druy induced-hepatic injury
王国俊 1罗宏丽 1冯碧敏 1胡馨2
作者信息
- 1. 泸州医学院 附属医院药剂科，四川泸州 646000
- 2. 泸州医学院 药学院，四川泸州 646000
- 折叠
摘要
Abstract
Objective:To investigate drug-induced hepatic injury for promoting clinical rational use of drugs. Methods: With “hepatic injury”and “adverse reactions” as keywords, drug-induced hepatic injury cases were retrieved from relevant databases from 2001 to 2011, analyzed and discussed. Results: 136 papers including 37 Summary reports, and 99 individual case reports with a total of 3344 cases of drug-induced hepatic injury were retrieved. 77.96% cases were via oral administration.Most clinical manifestations were jaundice, lassitude, and nonspecific digestive syste system. Liver cell damage was the most common type.The top five drugs that caused liver injury were TB drugs, traditional Chinese medicine, antibiotics, antineoplastics,antipyretic analgesics and anti-inflammatory drugs. Conclusion: A great variety of drugs can induce liver injury.Because of its non-specific clinical manifestation,and the possibility of its misdiagnosis and missed diagnosis,great importance should be at-tached to the monitoring and rational use of the related drugs.关键词
肝损害/药物性/文献分析Key words
Hepatic damage/Drug induced/Literature Analysis分类
医药卫生引用本文复制引用
王国俊,罗宏丽,冯碧敏,胡馨..药物性肝损害文献分析[J].泸州医学院学报,2013,(2):148-151,4.
