泸州医学院学报Issue(2)：157-160,4.
英夫利西单抗联合甲氨蝶呤治疗类风湿关节炎的疗效观察
Clinical observation of rheumatoid arthritis treated with infliximab combined with MTX
邓梅 1韩志伟 1马大卫2
作者信息
- 1. 内江市第一人民医院 风湿科，四川内江 641000
- 2. 内江市第一人民医院 药剂科，四川内江 641000
- 折叠
摘要
Abstract
Objective: To compare the efficacy and safety between infliximab (IFX ) combined with methotrexate (MTX) and leflunomide combined with MTX on the treatment of rheumatoid arthritis. Methods: 54 cases of RA in two groups were retrospectively analyzed. In infliximab treatment group, 31 patients were treated with infliximab 3mg/kg on the 0, 2 and 6 week, combined with methotrexate (MTX)10~15 mg per week. In the comparison group, 23 patients received the same dosage of MTX combined with leflunomide (LEF). The treatment course was 12 weeks. The indexes of efficacy assessment included the counts of joint tenderness,and joint swollen, patients’ full-scale assessment with visual analogue scale,and erythrocyte sedimentation rate (ESR);at the same time adverse events were registered. Results: After 6 and 12 weeks’ treatment,there were significant differences (P<0.05)between the two groups,and more patients in the experiment group ameliorated. DAS28 sug gested that the efficacy in the experiment group was better than that in the comparison one. No significant difference was found in adverse events between the two groups. Conclusion:The therapeutic efficacy of MTX combined with infliximab(IFX) on the treatment of rheumatoid arthritis is much better than that of LEF combined with MTX.关键词
英夫利西单抗/来氟米特/甲氨蝶呤/类风湿关节炎Key words
Infliximab/Leflunomide/Methotrexate/Rheumatoid arthritis分类
临床医学引用本文复制引用
邓梅,韩志伟,马大卫..英夫利西单抗联合甲氨蝶呤治疗类风湿关节炎的疗效观察[J].泸州医学院学报,2013,(2):157-160,4.
