国际眼科杂志Issue(11)：1873-1876,4.DOI:10.3980/j.issn.1672-5123.2015.11.09
兔眼玻璃体切除联合 C3 F8填充术后晶状体氧化损伤的研究
Research of T-SOD and MDA in rabbit lens at the early period after vitrectomy combined with nonexpansile perfluoropropane gas
杨艳芳 1贾松柏 2唐罗生2
作者信息
- 1. 400041 中国重庆市，重庆新视界眼科医院
- 2. 410011 中国湖南省长沙市，中南大学湘雅二医院眼科
- 折叠
摘要
Abstract
Abstract• AlM: To study the relationship between oxidative damage and the early pathological changes in rabbit lens after vitrectomy combined with nonexpansile perfluoropropane gas, by detecting T-SOD activity and MDA content at different stages after the operation.•METHODS:Fourty five healthy new zealand rabbits were divided randomly to three groups:normal group, control group and experimental group. The control group was just performed vitrectomy with BSS; the experimental group was performed vitrectomy combined with nonexpansile perfluoropropane gas. The lens were made into tissue homogenates to detect T-SOD activity and MDA content by using spectrophotometry on the 1st,3th,8th,35th and 45th day after the operation.•RESULTS:T-SOD activity: that in normal group was the hightest, that in experimental group was the lowest, and there was significant difference ( P<0. 01 ) among three groups in every periods after operation. MDA content: that in normal group was the lowest, that in experimental group was the hightest, and there was significant difference(P<0. 01)among three groups after the operation except the 1st day.•CONCLUSlON:Oxidative damage mechanism may be involved in the early damge of rabbit lens after vitrectomy combined with nonexpansile perfluoropropane gas.关键词
玻璃体切除术/全氟丙烷/白内障/氧化损伤Key words
vitrectomy/perfluoropropane gas/cataract/oxidative damage引用本文复制引用
杨艳芳,贾松柏,唐罗生..兔眼玻璃体切除联合 C3 F8填充术后晶状体氧化损伤的研究[J].国际眼科杂志,2015,(11):1873-1876,4.
