中南医学科学杂志Issue(6)：610-613,4.DOI:10.15972/j.cnki.43-1509/r.2015.06.003
HSP90α/β蛋白在胃癌组织中的表达及临床意义
The Clinical Significance and Expression of HSP90α/βProtein in Gastric Cancer Tissue
摘要
Abstract
Objective To verify clinical significance of the expression of heat shock protein 90α/β ( HSP90α/β) protein in gastric cancer tissue and provide valuable experiment data for gastric cancer patients on early diagnosis and clini-cal pathology grouping. Methods The expression of HSP90α/β protein was observed by immunohistochemistry staining in normal gastric mucosa tissue,cancer side tissue and gastric cancer tissue. Then the clinical pathology significance of the expression of HSP90α/βprotein was analyzed. Results The immunohistostaining results showed that the expressin posi-tive rate of HSP90α/βprotein was higher in gastric cancer tissue than that in normal gastric mucosa and cancer side tissue (P<0. 05),in cancer side tissue than that in normal gastric mucosa tissue (P<0. 05),in lymphaden metastatic gastric cancer tissue than that in no lymphaden metastatic gastric cancer tissue (P<0. 05) and inⅢ~Ⅳperiod patient gastric cancer tissue than that inⅠ~Ⅱperiod (P<0. 05). Conclusion The expression of HSP90α/βprotein was related with gastric cancer effluence,gastric cancer differentaiation level,lymphaden metastasis and TNM classification of gastric cancer. As the differentaiation level of gastric cancer tissue decreased,lymphaden metastasis of gastric cancer and TNM classifica-tion increased,the expression rate of HSP90α/β protein was also heightened.关键词
胃癌/HSP90α/β蛋白质/临床意义Key words
gastric cancer/HSP90α/β protein/clinical significance分类
医药卫生引用本文复制引用
雷艳,张志伟,刘重元,肖娟,张先锋,伍石华,周华茂..HSP90α/β蛋白在胃癌组织中的表达及临床意义[J].中南医学科学杂志,2015,(6):610-613,4.基金项目
湖南省自然科学衡阳联合基金( No.12JJ9033) （ No.12JJ9033）
湖南省自然科学基金( No.13JJ3079) （ No.13JJ3079）
湖南省科技厅项目( No.2013SK3118 （）
2014SK3081 （）
2014sk3073) （）
湖南省高校创新平台基金(No.12K094、No.13K082) （No.12K094、No.13K082）
衡阳市科技局项目(2013KJ02 （）
2013KJ12 （）
2013KJ28) （）
