内蒙古民族大学学报（自然科学版）Issue(3)：341-343,3.
可溶性血管内皮生长因子受体1在IgAN的研究进展
Research Progress of Soluble Vascular Endothelial Growth Factor Receptor-1 in IgAN
王志宏 1刘国平2
作者信息
- 1. 内蒙古呼和浩特市托克托县新营子镇中心卫生院，内蒙古 呼和浩特 010206
- 2. 内蒙古自治区人民医院 肾内科，内蒙古 呼和浩特 010017
- 折叠
摘要
Abstract
Soluble vascular endothelial growth factor receptor-1(sFlt-1)has been confirmed to be one of the molecu-lar markers of endothelial cell injury. In blood circulation, sFlt-1 regulates vascular endothelial growth factor(VEGF) function by binding it. By antagonizing the nutritional function of VEGF, sFlt-1 cause endothelial cell injury. Studies have found that blood sFlt-1 is significantly increased in chronic kidney disease(CKD)patients, and excess sFlt-1 is related with endothelial dysfunction. The IgA nephropathy(IgAN)is the most common disease in CKD, however, the correlative research of sFlt-1 in IgAN progress is absent at home and abroad. So the correlation study between sFlt-1 and IgAN in clinic and pathology is a brand-new research direction. Attention and research on the correlation between sFlt-1 with CKD, in particular with the high incidence of IgAN, and use their results correctly is a new idea for diagno-sis, treatment and prognosis of IgAN.关键词
可溶性血管内皮生长因子受体1(sFlt-1)/IgA肾病(IgAN)/CKDKey words
Soluble vascular endothelial growth factor receptor-1/IgA nephropathy/Chronic kidney disease分类
医药卫生引用本文复制引用
王志宏,刘国平..可溶性血管内皮生长因子受体1在IgAN的研究进展[J].内蒙古民族大学学报（自然科学版）,2013,(3):341-343,3.
