四川医学2015，Vol.36Issue(10)：1464-1466,3.DOI:10.16252/j.cnki.issn1004-0501-2015.10.032
孕11~14周静脉导管A波倒置在胎儿染色体异常中的筛查价值
Screening Value of Reversed A-wave in Fetal Ductus Venosus with Ultrasound on Chromosome Abnormalities at 11-14 Weeks Gestation
刘志辉 1邹翰琴 1王洁 1阳春芳 1张玉麒 1叶江 1颜嫒1
作者信息
- 1. 宜宾市第二人民医院超声科,四川 宜宾644000
- 折叠
摘要
Abstract
Objective To explore the clinical application value of the reversed A-wave in fetal ductus venosus assessed by ultrasound at 11~14 weeks gestation on screening fetal chromosomal abnormalities. Methods Regular antenatal examination was performed on pregnant women of 11~14 weeks gestation. The Doppler spectrum of the ductus venosus and the size of nuchal trans-lucency were conducted. The results of amniotic fluid puncture cultivate karyotype examination and the DV-RAW or NT thickening were followed up. Results Among 656 cases,DV-RAW were found in 21 cases,NT thickening were found in 19 cases,both in abnormalities were found in 12 cases. After followed-up of fetal chromosomal karyotype in 28 cases, chromosomal abnormalities were found in 17 cases,the trisomy 21 syndrome were found in 14 cases,Edwards' syndrome were found in 2 cases and 9 chromo-some structural abnormality was found only in 1 case. The sensitivity of DV-RAW in the detection of fetal chromosomal abnormali-ties was 82. 35%,the specificity was 36. 36% and the accuracy was 64. 29%. The sensitivity of NT thickening method in fetal chromosomal abnormalities was 76. 47%,the specificity was 45. 45% and the accuracy was 64. 29%. When combined the DV -RAW and NT methods,the diagnostic sensitivity was 58. 82%,the specificity was 81. 82% and the accuracy was 67. 86%. Con-clusion The reversed A-wave in fetal ductus venosus at 11~14 weeks gestation showed to be helpful in the early screening for fe-tal chromosomal abnormalities,and might help the early diagnosis of fetal abnormal chromosome karyotype.关键词
超声检查/静脉导管/多普勒/染色体异常Key words
ultrasound/ductus venosus/dopple/chromosome abnormalities分类
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刘志辉,邹翰琴,王洁,阳春芳,张玉麒,叶江,颜嫒..孕11~14周静脉导管A波倒置在胎儿染色体异常中的筛查价值[J].四川医学,2015,36(10):1464-1466,3.
