四川医学Issue(11)：1549-1551,1552,4.DOI:10.16252/j.cnki.issn1004-0501-2015.11.017
不同剂量右美托咪定对妇科恶性肿瘤腹腔镜手术围术期肾功能的影响
Effect of Dexmedetomidine with Different Dosages on the Perioperative Renal Function in Patients Undergoing Lapa-roscopic Resection Surgery for Gynecologicmalignant Tumors
摘要
Abstract
Objective To explore the effect of different dose of dexmedetomidine on the perioperative renal function in patients undergoing resection surgery for gynecologic malignant tumors. Methods One hundred patients were assigned randomly into 4 groups:control group, study group 1, study group 2, and study group 3. Patients in the study groups were administered 0. 4μg/ (kg·h) of dexmedetomidine for 10 min during the anesthesia induction, and were infused intravenously with dexmedetomi-dine at 0. 1 μg/ (kg·h)(study group 1), 0. 2 μg/ (kg·h)(study group 2), 0. 4 μg/ (kg·h)(study group 3)until the surgery completed. The values of HR, MAP, urine volume and neutrophil gelatinase associated lipocalin(NGAL)at different time points were recorded. Results Urine volume within 120 min after the pneumoperitoneum inflation in study group 2 and study group 3 were higher than in study group 1 and control group, and that in study group 3 was higher than in study group 2(P < 0. 001). U-rine volume within 120 min after the surgery completeness in study group 3 was higher than in other three groups(P < 0. 05), and no difference was found in urine volume among the control group, study group 1 and study group 2. NGAL in study group 2 and study group 3 were higher than in study group 1 and control group(P < 0. 001), and there was no difference between study group 2 and study group 3 as well as between study group 1 and control group. Conclusion In patients undergoing laparoscopic resection surgery for gynecologic malignant tumors, dexmedetomidine could improve the intraoperative hemodynamic response as well as perioperative renal function indicated by promoting urine production and alleviating the NGAL elevation caused by surgery, and this effect is in a manner of dose dependent.关键词
右美托咪定/肾功能/腹腔镜/妇科/恶性肿瘤Key words
dexmedetomidine/renal function/laparoscope/resection surgery/gynecologic malignant tumors分类
医药卫生引用本文复制引用
徐晓燕,吴畏..不同剂量右美托咪定对妇科恶性肿瘤腹腔镜手术围术期肾功能的影响[J].四川医学,2015,(11):1549-1551,1552,4.
