四川医学Issue(11)：1583-1586,4.DOI:10.16252/j.cnki.issn1004-0501-2015.11.030
钆塞酸二钠增强 MRI 在肝硬化背景下对肝癌诊断价值的 Meta 分析
Gadoxetic Acid Disodium-Enhanced Magnetic Resonance Imaging for the Detection of Hepatocellular Carcinoma in Patients with Cirrhosis-A Systematic Review and Meta-Analysis
张凌 1梁娜 1范萍2
作者信息
- 1. 成都市第二人民医院影像科，四川 成都 610017
- 2. 成都军区总医院干部病房，四川 成都 610083
- 折叠
摘要
Abstract
Objective To perform a systematic review and meta-analysis of the diagnostic performance of gadoxetic acid disodium(Gd-EOB-DTPA)- enhanced magnetic resonance imaging(MRI)as noninvasive modality for evaluating hepatocellular car-cinoma(HCC)in patients with cirrhosis. Methods Databases including MEDLINE , EMBASE, and Cochrane Library databases were searched for relevant original articles published from January 2000 to March 2015. Sensitivities, specificities,and areas under the receiver operating characteristic curve(AUC)were calculated. Potential threshold effect, heterogeneity, and publication bias were investigated. Results Across 16 studies of 2474 lesions were included. The overall per-lesion Gd-EOB-DTPA- enhanced MRI sensitivity was 0. 921(95% CI:0. 887,0. 946), and specificity was 0. 909(95% CI:0. 823,0. 955). The area under the curve of the summary receiver operator characteristic(ROC)was 0. 96(95% CI:0. 94,0. 97). Conclusion MRI with gadoxetic acid disodium is a noninvasive and no radiation exposure imaging modality with high sensitivity and specificity for the detection of HCC in patients with cirrhosis. Nonetheless, large-scale well-designed trials are necessary to assess its clinical value.关键词
钆塞酸二钠/肝细胞肝癌/Meta 分析Key words
gadoxetic acid disodium/hepatocellular carcinoma/Meta-analysis分类
医药卫生引用本文复制引用
张凌,梁娜,范萍..钆塞酸二钠增强 MRI 在肝硬化背景下对肝癌诊断价值的 Meta 分析[J].四川医学,2015,(11):1583-1586,4.
