摘要
Abstract
Objective:ErbB2 overexpression correlates with increased expression of vascular endotheliai growth factors A , C,and D in human breast carcinoma. Methods:The expression levels of VEGF -A,VEGF-C,and VEGF-D protein in 107 breast carcinoma cases and 22 nonmalignant breast tissue samples were examined by immunohistochemistry Results:Higher expression of VEGF -C and VEGF-D was found in breast carcinomas than in nonmal ignant breast tissue samples .Moreover,expression of VEGF-A, VEGF-C,and VEGF-D was significantly and positively correlated with ErbB 2 expression.High levels of VEGF -A expression were associated with shorter disease-free survival ( DFS) .Patients with tumors expressinghigh levels of VEGF -C or VEGF-D showed a notable trend for worse DFS , however ,it was not statlsticallysignificant .The combination of VEGF-A and VEGF-C status predicted survival better than either marker-alone.Conclusion:Our study suggests that expression of the angiogenic and lymphangiogenic factors (i.e.,VEGFs)might bc regulated at least in part by ErbB2.In addition, the combination of VEGF-A andVEGF-C status may better predict prognosis Of patients with breast carcinoma than VEGF-A alone.关键词
乳腺癌/VEGF-A/VEGF-C/VEGF-D/ErbB2Key words
Breast carcinoma/VEGF -A/VEGF-C/VEGF-D/ErbB2分类
医药卫生
