摘要
Abstract
Objective:Observation and evaluation of fluoroquinolones in combination with a one second -line anti-TB drugs to treat multidrug-resistant tuberculosis ( MDR-TB) Clinical efficacy and safety .Methods:156 cases of MDR-TB patients were randomly di-vided into two groups, in which the observation group adopted 6MfxZPtoKmPAS/18MfxZPtoPAS Chemotherapy;Controlgroupdopted6LfxZPtoKmPAS/18LfxZPtoPAS chemotherapy, Treatment for 24 months.Results:Observation group of 79 patients, 62 cases had marked effect, total effective rate was 96.20%, Control group 77 patients in 49 cases had marked effect, total effective rate was 84.42%, Comparison of clinical efficacy difference was significant (P<0.01), Observation group the patients 3 months, 12 months spu-tum negative rate were 55.69%, 73.42%, 24 months of treatment at the end of the cumulative sputum negative rate 68patients, sputum negative rate were 86.08%, Significantly higher than that of the control group , and the difference was statistically significant (P<0.05), Observation group the incidence of adverse reactions was 16.46%(13/79); The control group was 15.58%(12/77), The difference between the two groups was not statistically significant (P>0.05).Conclusion:fluoroquinolones in combination with a one second -line anti-TB drugs to treat multidrug -resistant tuberculosis ( MDR-TB) Clinical No cross resistance in curative effect is distinct , and has higher security .关键词
氟喹诺酮类药物/莫西沙星/左氧氟沙星/耐多药结核病/化疗方案/疗效Key words
Fluoro-quinolon/Moxifloxacin/Levofloxacin/Multidrug-resistant tuberculosis(MDR-TB)/Chemotherapy/Efficacy分类
医药卫生
