中国伤残医学Issue(8)：68-69,2.
局部亚低温延长急性脑梗死溶栓治疗时间窗的疗效研究①
Curative effect and safety of local mild hypothermia treatment to extend time window of thrombolytic of acute cerebral infarction
摘要
Abstract
Objective:To explore the curative effect and safety of local mild hypothermia treatment to extend time window of thrombo -lytic of acute cerebral infarction on multi -modality magnetic resonance imaging ( MRI) -based.Methods: According to thrombolysis conditions based on MRI,63 cerebral infarction patients (6 to 12 hours between) were chosen.They were randomized into 3 groups,local mild hypothermia group ,thrombolysis group and control group respectively .All patients were given conventional therapy .The urokinase thrombolysis treatment and local mild hypothermia were used in first groups and the thrombolysis treatment in second group .Compared the National Institutes of Health Stroke Scale (NIHSS) score and the total effective rate before,and 24h,14d and 90d after treatment.Re-sults:The 14d and 90d NIHSS score of local mild hypothermia group and thrombolysis group decreased significantly (P<0.05).The 90d NIHSS score of local mild hypothermia group was lower than thrombolysis group ( P<0.05) .The total effective rate of two groups had no big difference (P>0.05).Conclusion:Based on MRI,many patients which are beyond the specified time window benefit from thrombol-ysis treatment .The long-term curative effect of local mild hypothermia treatment should be better than thrombolysis treatment only .关键词
急性脑梗死/局部亚低温/溶栓时间窗/磁共振成像Key words
Acute cerebral infarction/Local selective and mild hypothermia/Time window of thrombolytic therapy/Magnetic reso-nance imaging分类
医药卫生引用本文复制引用
伍丽红,徐树军,惠凯,朴影,杨巍,李宏,耿红梅..局部亚低温延长急性脑梗死溶栓治疗时间窗的疗效研究①[J].中国伤残医学,2013,(8):68-69,2.基金项目
黑龙江省卫生厅立项项目 （）
