中国伤残医学Issue(20)：31-33,3.DOI:10.13214/j.cnki.cjotadm.2015.20.021
重复经颅磁刺激联合奥氮平治疗急性期精神分裂症幻听的疗效及安全性研究
The Efficacy and Safety Study to Acute Schizophrenia with Auditory Hallucination by Repetitive Transcranial Magnetic Stimulation(rTMS) with Olanzapine Therapy
路广义 1和会宁 1何磊1
作者信息
- 1. 驻马店市第二人民医院，河南驻马店 463000
- 折叠
摘要
Abstract
Objective:The efficacy and safety study to acute schizophrenia with auditory hallucination by repetitive transcranial mag-netic stimulation ( rTMS) with olanzapine therapy.Methods:80 schizophrenia with auditory hallucination were randomly divided into treatment group (40 cases) and control group (40 cases) .Treatment group given 1 hz rTMS stimulation ten times, 20 minutes every time. but no rTMS stimulation to control group.At the same time the two groups were given olanzapine treatment for 14 days.By using positive and negative symptoms scale ( PANSS) , auditory hallucinations scale ( AHRS) and the clinical global impression scale( CGI) to evaluate the therapeutic effect.Treatment emergent symptoms scale( TESS) to assess the side effects.Results:37 cases of treatment group com-plete the study, 36 cases of control group complete the study.At the end of the study, P3(hallucinatory behavior) score from PANSS in treatment group and the AHRS score were lower than the control group (t =5.85, 5.10;P <0.05), but the PANSS scores and CGI-SI (severity of illness)were no statistically significant difference in two groups (t =1.25, 1.56;P >0.05).there was no statistically significant difference to TESS in two groups (c2 =0.34, P =0.34), there were no serious adverse reactions.Conclusion:there are obvious curative effect and good safety to schizophrenia with auditory hallucination by Olanzapine combine low frequency rTMS.关键词
重复经颅磁刺激/精神分裂症/幻听/对照研究Key words
Repetitive transcranial magnetic stimulation/Schizophrenia/Auditory hallucinations/Control study分类
医药卫生引用本文复制引用
路广义,和会宁,何磊..重复经颅磁刺激联合奥氮平治疗急性期精神分裂症幻听的疗效及安全性研究[J].中国伤残医学,2015,(20):31-33,3.
