药学研究Issue(11)：628-630,647,4.
山楂叶总黄酮对大鼠缺血脑组织 P38蛋白表达的影响
Effect of total flavone of Hawthorn leaf on p38 protein in brain of the chronic cerebral ischemia rats
摘要
Abstract
Objective To investigate the therapeutic effect and mechanism that total flavone of Hawthorn leaf(TFHL) on p38 protein in brain of the chronic cerebral ischemia rat. Methods Male healthy SD rats were randomly divided into sham group,model group,TFHL group and Ginkgo leaf group. Permanent bilateral carotid artery ligation was used to prepare chronic cerebral ischemia model. Morris water maze method was used to evaluate learning and memory abilities of rats;Western blot method was used to measure the expression of p38 protein(P < 0. 05). Results Compared with the model group,TFHL treatment can improve learning and memory capabilities of vascular dementia rats,shorten the escape latency (P < 0. 05),increase the number of crossing the platform(P < 0. 05)and dramatically inhibit the expression of p38 protein (P < 0. 05). Conclusion TFHL played a protective role to nerve function of the chronic cerebral ischemia rat. The mecha-nism of its anti - apoptosis might be associated with down - regulating expression of p38 protein,reduced the apoptosis of neuron in the brain.关键词
山楂叶总黄酮/慢性脑缺血/学习记忆/p38 蛋白Key words
TFHL/Chronic cerebral ischemia/Learning and memory/p38 protein分类
医药卫生引用本文复制引用
李蒙蒙,赵星龙,尹美娟,张强,吴晓光,赵淑敏,白江涛..山楂叶总黄酮对大鼠缺血脑组织 P38蛋白表达的影响[J].药学研究,2015,(11):628-630,647,4.基金项目
河北省科技厅指令课题（No.15277789D）；河北省教育厅青年基金指令课题（No. QN2014103）；河北省高校省级重点学科资助项目（No.2013）；河北省中医药抗痴呆重点研究室建设项目资助（No.2014-2017）；承德医学院大学生科研重点资助项目 （）
