山东医药Issue(39)：79-81,3.DOI:10.3969/j.issn.1002-266X.2015.39.032
痰热清注射液治疗全身炎症反应综合征的系统评价
Systematic review of Tanreqing injection in treatment of systemic inflammatory response syndrome
摘要
Abstract
Objective To evaluate the efficacy of Tanreqing injection in treatment of systemic inflammatory response syndrome (SIRS) systematically.Methods We retrieved Ovid/Pubmed, Embase, CNKI, Wanfang data, VIP and Chi-nese biomedical literature database to search for the randomized controlled trial ( RCT) of Tanreqing injection in the treat-ment of SIRS , and then we observed the following indexes , including the clinical total effective rate , white blood cell count (WBC), serum C-reactive protein (CRP) and serum tumor necrosis factor-α(TNF-α), serum calcitonin (PCT) and tem-perature ( T) .According to the Jadad quality evaluation , we evaluated the literatures .Results Eleven trials were eligible finally, and contained 811 cases of patients including 396 patients treated with conventional treatment and 415 with Tan-reqing injection based on conventional treatment , only one literature was of high-quality.Meta analysis showed that the therapeutic effect of SIRS treated with Tanreqing injection was better than that treated by routine alone , and it reflected mainly in the following:the total clinical efficiency was increased (OR=3.05, 95%CI:1.46-6.39, P=0.003), the level of WBC (WMD=1.39,95%CI:2.25 to 0.53, P=0.002), the level of CRP (WMD=13.78, 95%CI:19.96 to 7.60, P<0.00 01), the level of PCT (SMD=2.17, 95%CI:4.23 to 0.11, P=0.04), the level of TNF-α(SMD=-1.50, 95%CI:2.14 to 0.85, P<0.00 001), and the level of IL-6 (WMD=-24.04,95%CI:36.03 to 12.05, P<0.00 01) were decreased, ant the level of T was decreased (WMD=-0.66, 95%CI:0.85 to 0.47, P<0.00 01).No serious adverse reactions were reported .Conclusion Tanreqing injection has good effect in treatment of SIRS .关键词
痰热清注射液/全身炎症反应综合征/Meta分析Key words
Tanreqing injection/systemic inflammatory response syndrome/meta analysis分类
医药卫生引用本文复制引用
武珊珊,于强..痰热清注射液治疗全身炎症反应综合征的系统评价[J].山东医药,2015,(39):79-81,3.基金项目
天津市中医药管理局中医中西医结合科研课题（13046）。 （）
