山东医药Issue(42)：4-6,3.DOI:10.3969/j.issn.1002-266X.2015.42.002
小儿室间隔缺损修补术中乌司他丁及氨甲环酸联用的效果及临床意义
Effect of ulinastatin and tranexamic acid on inflammatory and coagulation indexes in children undergoing ventricular septal defect repair
摘要
Abstract
Objective To explore the effect of ulinastatin and tranexamic acid on inflammatory and coagulation indexes in children undergoing ventricular septal defect repair .Methods A total of 200 children diagnosed with ventricular septal defect were divided into four groups, 50 cases in each group: ulinastatin group (group A), tranexamic acid group (group B) , combination group ( group C) and the control group .The volume of drainage from pericardium and frozen plasma infusion volume during the operation were recorded .We took the blood from the central venous catheter before and 12 hours after oper-ation to detect the serum inflammatory indexes , including tumor necrosis factor-α( TNF-α) , interleukin-6 ( IL-6) and inter-leukin-10 (IL-10), and coagulation indexes, including neutral grain of elastase, prothrombin time (PT) and activated partial thromboplastin time ( APTT) .Results The volume of drainage from pericardium and frozen plasma infusion volume of the groups A, B and C were less than that of the control group , and the combination group was less than the other groups ( all P<0.05).The serum levels of TNF-αand IL-6 in the groups A, B and C were lower than that of the control group , and group C was lower than the other two groups;the serum level of IL-10 in the groups A, B and C were higher than that of the control group, and group C was higher than the other two groups;the serum levels of elastase , PT and APTT in the groups A, B and C were lower than that of the control group , and group C was lower than the other two groups ( all P<0.05) .Conclusion The ulinastatin and aminomethylbenzoic acid have hemostatic and anti-inflammatory effect in children undergoing ventricular septal defect repair , which can reduce the volume of drainage from pericardium and frozen plasma infusion volume during the operation, and it may be related with the promotion of coagulation and inhibition of inflammatory reaction .关键词
乌司他丁/氨甲环酸/室间隔缺损/炎症/凝血Key words
ulinastatin/aminomethylbenzoic acid/ventricular septal defect/inflammation/coagulation分类
医药卫生引用本文复制引用
刘延芹,李素玲,赵海涛,赵砚丽,高义,杨永辉..小儿室间隔缺损修补术中乌司他丁及氨甲环酸联用的效果及临床意义[J].山东医药,2015,(42):4-6,3.基金项目
河北省医学科学研究重点课题计划资助项目（20110015）。 （）
