山东医药Issue(43)：34-35,36,3.DOI:10.3969/j.issn.1002-266X.2015.43.012
孕妇外周血胎儿有核红细胞计数变化及其在不良妊娠结局预测中的应用
Fetus nucleated red blood cell count changes in peripheral blood of pregnant women and its application in prediction of adverse pregnancy outcomes
摘要
Abstract
Objective To observe the fetus nucleated red blood cell ( NRBC) count changes in the peripheral blood of pregnant women and to investigate its application in prediction of adverse pregnancy outcomes. Methods Blood samples were obtained from 87 pregnant women with the gestational age from 12 to 18 weeks, peripheral blood mononuclear cells were isolated by density gradient centrifugation and then we analyzed the cells marked with PE-GPA/FITC-CD71 mono-clonal antibodies on the flow cytometer. Tracking the pregnancy outcomes, and their correlation between fetus nucleated red blood cell measurement and adverse pregnancy outcomes was analyzed. Results The percentage of fetus NRBC in women with normal pregnancy outcomes was 0. 89% ± 0. 81%, 3. 25% ± 2. 98% in women with adverse pregnancy outcomes, and there was a significant difference between these two groups(P<0. 05). We took fetus NRBC percentage >3. 79% as the cutoff value to predict adverse outcomes of pregnancy, the sensitivity was 76. 9%, and the specificity was 64. 3%. Conclu-sions Compared with women with normal pregnancy outcomes, women with adverse pregnancy outcomes have a higher a-mount of fetus NRBC in the peripheral blood during the gestational age of 12-18 weeks. Measurement of fetus NRBC in ma-ternal peripheral blood has a predictive role in adverse pregnancy outcomes, with a higher sensitivity and specificity.关键词
有核红细胞/胎儿有核红细胞/妊娠/孕妇/妊娠结局Key words
nucleated red blood cells/fetus nucleated red blood cells/pregnancy/pregnant women/pregnancy outcome分类
医药卫生引用本文复制引用
刘丽平,水丽君,龚瑞龙,曹江霞,黄秋香,张元珍..孕妇外周血胎儿有核红细胞计数变化及其在不良妊娠结局预测中的应用[J].山东医药,2015,(43):34-35,36,3.基金项目
湖北省武汉市卫生和计划生育委员会2014年立项课题。 （）
