生物骨科材料与临床研究Issue(2)：5-8,4.
水溶性 O-羟乙基壳聚糖接枝聚乳酸的制备与表征*
Synthesis and characterization of Water soluble O-hydroxyethyl chitosan graft polylactic acid
摘要
Abstract
Objective To fabricate water-soluble O-hydroxyethyl chitosan/ploylactic acid fibers composite scaffold for tissue engineering. Methods First, the water-soluble O-hydroxyethyl chitosan was prepared by the reaction of chitosan with ethylene oxide, then the body sealing tube polymerization, with stannous octoate as catalyst, water-soluble O-hy-droxyeth-yl chitosan for initiator cause D, L-lactide ring-opening polymerization preparation of water-soluble O-hydro-xyethyl chitosan-g-polylactic acid copolymer. Using X-ray diffraction, infrared spectrum and scanning electron micro-scopy and dissolving experiment were adopted to characterize and analyze the degraded products. Results The modific-ation of the water-soluble O-hydroxyethyl chitosan can obviously improve the dissolution performance, reduce the cry-stallization properties and the hydrogen bonding interaction. Conclusion Water soluble O-hydroxyethyl chitosan/poly-lactic acid copolymer can been obtained with the chemical modification, and then put into use in drug eluting stent because it has a good porosity and mesh. In addition, modified copolymer is soluble in some of the most common organic solvents, and it’s helpful in the further application in tissue engineering.关键词
壳聚糖/水溶性O-羟乙基壳聚糖/聚乳酸/接枝共聚物/本体聚合Key words
Chitosan/Water soluble O-hydroxyethyl chitosan/Polylactic acid/Graft copolymer分类
化学化工引用本文复制引用
刘胜理,李晓峰,舒勇,谢宇,刘超..水溶性 O-羟乙基壳聚糖接枝聚乳酸的制备与表征*[J].生物骨科材料与临床研究,2013,(2):5-8,4.基金项目
江西省自然科学基金(20114BAB205045) （20114BAB205045）
