生物技术通报Issue(10)：48-55,8.DOI:10.13560/j.cnki.biotech.bull.1985.2015.10.011
细菌群体感应信号分子淬灭酶的研究进展
Research Progress on Bacterial Quorum Quenching Enzymes
摘要
Abstract
Quorum sensing(QS)is a phenomenon of intercellular communication of bacteria via signal molecules. Bacteria secrete the specific signal molecules and respond to them, and bacterial cells enable the expression of specific genes, especially disease-causing genes while the signal molecules accumulate to a threshold concentration. This provides a new thought to prevent plants and animals from bacterial pathogenicity. Quorum quenching(QQ)based on QS system is a schema to decompose the signal molecules beyond the threshold concentration, and therefore represses the expression of specific virulence gene, so finally the prevention and control of diseases are achieved. The enzymes of QQ have been explored the most and also proved to be the most effective ways of quenching. To date, many QQ enzymes have been isolated successfully. Here we review progress on QQ enzymes with aspects of their type, property, catalytic mechanism, and physiologic function.关键词
群体感应/群体淬灭/分子淬灭酶/酰基高丝氨酸内酯酰基转移酶/酰基高丝氨酸内酯酶Key words
quorum sensing/quorum quenching/molecule quenching enzyme/acyl homoserine acylase/acyl homoserine lactonase引用本文复制引用
邢启凡,柳鹏福,史吉平,孙玉梅..细菌群体感应信号分子淬灭酶的研究进展[J].生物技术通报,2015,(10):48-55,8.基金项目
国家基金委青年科学基金项目 （）
