生物技术通报Issue(10)：56-61,6.DOI:10.13560/j.cnki.biotech.bull.1985.2015.10.012
镉诱导细胞自噬的研究进展
Research Progress on Cell Autophagy Induced by Cadmium
摘要
Abstract
Cadmium, a highly toxic heavy metal, has been proven to be hazard for both human health and environment. Growing evidences have confirmed that cadmium caused damages to multiple organs and systems, and even led to cancer and tumors. Autophagy is an evolutionarily conserved lysosomal pathway of degrading cytoplasmic proteins and organelles. On the one hand, autophagy represents a cell survival mechanism to clear damaged organelles for preventing the cells from the further damages induced by cadmium;on the other hand, it may lead to cell death as cell death mechanism while the damage to the cell is irreversible. It is found that the role of autophagy in cadmium-induced cytotoxicity is still controversial, which might be caused from the variations on concentration and exposure time of cadmium. Current investigations on the mechanism of autophagy are mainly focusing on signal molecules of mTOR, Ca2+and Beclin-1. Studies of the molecular mechanism between cadmium and autophagy can provide new ideas for the treatment and prevention of cadmium poisoning. This review summarizes the role of autophagy in cytotoxicity and signaling pathways in the autophagy induced by cadmium.关键词
镉/自噬/生存/死亡/信号通路Key words
cadmium/autophagy/survival/death/signaling pathway引用本文复制引用
王棋文,宋德荣,刘其昌,周大荣,彭华,张琼娣,罗耀..镉诱导细胞自噬的研究进展[J].生物技术通报,2015,(10):56-61,6.基金项目
国家现代农业产业技术体系专项资金（CARS-40-30，CARS-40-46），贵州省联合基金资助项目［LKB 2013（02）］，河南师范大学博士启动课题（qd14175），贵州省国际科技合作计划项目［黔科合外G字（2014）7005号］，贵州省农业动植物育种专项［黔农育专字（2014）019号］，毕节市农业攻关计划项目［毕科合字（2014）34号］，毕节试验区肉羊产业发展研究人才团队［毕人领办通（2013）7号］ （）
