生物信息学2015，Vol.13Issue(3)：192-197,6.DOI:10.3969/j.issn.1672-5565.2015.03.08
血清microRNA-152和microRNA-602检测在肝癌诊断及手术疗效评估中的应用
Study on the expression and diagnostic significance of microRNA-152 and microRNA-602 in hepatocellular carcinoma
周轶冰1
作者信息
- 1. 佳木斯市中心医院普外科,黑龙江 佳木斯154002
- 折叠
摘要
Abstract
To explore the application value of microRNA-152 and microRNA-602in the diagnosis of liver cancer and evaluation of therapeutic effects. The serum microRNA was extracted, and the levels of circulating microRNA-152 and microRNA-602 were quantified by real-time quantitative RT-PCR. Expression differences of microRNA-152 and microRNA-602 were analyzed in every experimental groups. Results show the expression level of the HBV positive hepatocellular carcinoma microRNA-152 was significantly lower than that in the healthy group( p<0.05) , while the expression level of microRNA-602 was higher than that in the healthy group ( p<0. 05 ) . It is speculated that microRNA-152 and microRNA-602 may be employed as novel serum markers for the diagnosis of HBV-positive liver cancer and microRNA-152 may be employed as novel serum markers for the evaluation of therapeutic effect.关键词
HBV/肝癌/MicroRNA-152/MicroRNA-602Key words
Hepatitis B Virus/Hepatocellular Carcinoma/MicroRNA-152/MicroRNA-602引用本文复制引用
周轶冰..血清microRNA-152和microRNA-602检测在肝癌诊断及手术疗效评估中的应用[J].生物信息学,2015,13(3):192-197,6.
