山西医科大学学报2015，Vol.46Issue(10)：959-961,3.DOI:10.13753/j.issn.1007-6611.2015.10.002
右美托咪定对缺血再灌注损伤大鼠心肌VEGF表达的影响
Effects of dexmedetomidine on expression of VEGF in myocardium of rats with myocardial ischemia-reperfusion injury
党旭云 1蔚俊星 2李静1
作者信息
- 1. 西安医学院第一附属医院麻醉科,西安 710077
- 2. 西安市第四医院麻醉科
- 折叠
摘要
Abstract
Objective To explore the effect of dexmedetomidine on the expression of vascular endothelial growth factor( VEGF) in my-ocardium of myocardial ischemia-reperfusion injury rats. Methods Forty healthy male SD rats were randomly divided into 4 groups:sham group( A) , MIRI group( B) , MIRI+Dex 10 μg/kg group( C) , MIRI+Dex 30 μg/kg group( D) . The left anterior descending coronary artery was ligated for establishing the rat myocardial ischemia-reperfusion injury model in vivo. Immunohistochemistry was used to analyze the expression of VEGF. Results Compared with group A,the expression of VEGF was reduced in group B and group C(P<0. 05). Compared with group B, the expression of VEGF was increased in group C and group D(P<0. 05). The expression in group D was significantly higher than in group C(P<0. 05). Conclusion Preconditioning of dexmedetomidine can have protective effects on the myocardium by up-regulating the expression of VEGF.关键词
右美托咪定/心肌/缺血再灌注损伤/血管内皮生长因子Key words
dexmedetomidine/myocardium/ischemia-reperfusion injury/vascular endothelial growth factor( VEGF)分类
医药卫生引用本文复制引用
党旭云,蔚俊星,李静..右美托咪定对缺血再灌注损伤大鼠心肌VEGF表达的影响[J].山西医科大学学报,2015,46(10):959-961,3.
