实用肝脏病杂志Issue(1)：32-34,3.DOI:10.3969/j.issn.1672-5069.2013.01.011
恩替卡韦治疗慢加急性乙型肝炎肝衰竭近期疗效评价
Short-ter m survival of entecavir administration in patients with acute-on-chronic hepatitis B liver failure
占国清 1李芳 1李刚 1张薇薇 1雷飞飞 1李儒贵 1谭华炳1
作者信息
- 1. 442000 湖北省十堰市 湖北医药学院附属人民医院肝病研究所
- 折叠
摘要
Abstract
Objective To evaluate the efficacy of entecavir treatment in patients with acute-on-chronic hepatitis B liver failure. Methods 68 patients with acute-on-chronic hepatitis B liver failure were divided into treatment group (n=42 )and control group (n=26). Patients in control group was given the conventional therapy, while those in treatment group was treated with entecavir at dose of 0.5mg daily on the bases of routine treat-ment. After 12 week treatment,the changes of blood biochemical index,prothrombin activity,HBV DNA,MELD scores and mortality rates in the two groups were evaluated. Results At 12 weeks of treatment, the total serum bilirubin and HBV DNA levels in the treatment group were 89.7±42.5μmol/L and 3.16±2.04 log10copies/mL,sig-nificantly lower than those in the control group (145.6±64.2μmol/L and 6.28±3.95 log10copies/mL,P<0.01);Pro-thrombin time activity and albumin in the treatment group were 48.5±15.6% and 34.8±4.8g/L,significantly higher than those in control group(40.5±12.4% and 30.2±4.1g/L,P<0.05 or P<0.01);MELD scores and mortality rates in early and middle stage patients in treatment group were 17.6±3.5 and 20%,significantly lower than those in the control group(22.4±4.1 and 52.9%,P<0.05 or P<0.01);There were no significant differences in MELD scores and mortality rates in late stage patients in the two groups (P>0.05). Conclusion Entecavir can effectively suppress HBV replication,improve liver function in patients with acute-on-chronic hepatitis B liver failure. Early antiviral therapy can improve survival rate of patients with acute-on-chronic hepatitis B liver failure.关键词
慢加急性乙型肝炎肝衰竭/恩替卡韦/病死率Key words
Hepatitis B/Acute-on-chronic liver failure/Entecavir/Mortality引用本文复制引用
占国清,李芳,李刚,张薇薇,雷飞飞,李儒贵,谭华炳..恩替卡韦治疗慢加急性乙型肝炎肝衰竭近期疗效评价[J].实用肝脏病杂志,2013,(1):32-34,3.
