实用肝脏病杂志Issue(1)：43-45,3.DOI:10.3969/j.issn.1672-5069.2013.01.015
核苷（酸）类似物治疗对乙型肝炎病毒感染者聚合酶区基因变异的影响
Mutation of hepatitis B viral polymerase motif in patients with chronic hepatitis B receiving nucleos(t) ides treatment
潘洪洋 1杨方 1张明香 1魏倪 1杨桦 1林松1
作者信息
摘要
Abstract
Objective To investigate the mutation of hepatitis B viral polymerase motif in patients with chronic hepatitis B receiving nucleos (t)ides treatment. Method The HBV polymerase reverse transcriptase genes in 481 patients with chronic hepatitis B infection was analysed by direct sequencing. The patients were divided into 3 groups:never applying to nucleoside analogue(NA,group 1),applying to NA before (group 2) and applying to NA at the moment of study (group 3). Results The missense variations in group 1,2 and 3 were found in 6 (2.0%),4(8.2%) and 50(38.5%),while the homonymy variations in group 1,2 and 3 were found in 25(8.5%),5 (10.2%)and 20 (15.4%),respectively;Out of group 3, the serum HBV DNA levels were 5.58±1.36lgcopies/ml in patients with missense variation,5.27 ±1.05lgcopies/ml in with homonymy variation and 4.98 ±1.50lgcopies/ml in without variation,respectively (P>0.05). Conclusion Further investigation of HBV variation may help solve the problem of drug resistance in patients with hepatitis B.关键词
慢性乙型肝炎/乙型肝炎病毒/核苷(酸)类似物/耐药突变Key words
Hepatitis B/Hepatitis B virus/Mutation/Nucleoside analogues引用本文复制引用
潘洪洋,杨方,张明香,魏倪,杨桦,林松..核苷（酸）类似物治疗对乙型肝炎病毒感染者聚合酶区基因变异的影响[J].实用肝脏病杂志,2013,(1):43-45,3.
