实用肝脏病杂志Issue(4)：317-319,3.DOI:10.3969/j.issn.1672-5069.2013.04.010
中药和西药致急性药物性肝损伤临床和肝组织病理学特征对比分析*
Comparative analysis of clinical and hepatic pathologic features in patients with acute drug-induced ;liver injury caused by traditional Chinese herbs and western medicines
摘要
Abstract
Objective To compare the clinical and hepatic pathologic features in patients with acute drug-induced liver injury (ADILI) caused by traditional Chinese herbs and western medicines. Methods The clinical parameters were obtained and liver biopsies were performed in patients with ADILI induced by traditional Chinese herbs (group A,n=96) or by western medicines (group B,n=113). Results There was no significant difference in clinical features (i.e. fatigue,poor appetite,nausea,abdominal distension,pruritus,fever) and biochemical serum parameters (ALT,AST,AKP,GGT,total bilirubin) in the two groups; in contrast to a rate of 14.2%(P<0.05)in group B,27.1% of patients in group A were positive for certain serum autoimmune antibodies; spotted and focal necrosis in liver tissues were similar between the two groups (93.8% vs.94.7%,P>0.05),however,confluent necro-sis(51.0% vs. 33.6%),interface inflammation (65.6% vs.50.4%) and fibrous septa formations (54.2% vs.37.2%) in group A were significantly higher than those in group B (P<0.05),and lymphoplasmacytic infiltrates in group A(26.04%)were significantly higher than that in group B(19.5%,P>0.05). Conclusions Even though the clinical features and biochemical parameters in patients with ADILI caused by traditional Chinese herbs and western medicines are similar,traditional Chinese herbs are more likely to cause autoimmune responses and more severe hepatic pathological changes than western medicines.关键词
药物性肝损伤/中药/西药/病理学/自身免疫Key words
Drug-induced liver injury/Traditional Chinese herbs/Western medicines/Liver pathology/Au-toimmune response引用本文复制引用
柳芳芳,段学章,臧红,郭晓东,申力军,赵攀,胡瑾华,辛绍杰..中药和西药致急性药物性肝损伤临床和肝组织病理学特征对比分析*[J].实用肝脏病杂志,2013,(4):317-319,3.基金项目
国家“十二五”科技重大专项课题 （）
