实用肝脏病杂志Issue(4)：341-343,3.DOI:10.3969/j.issn.1672-5069.2013.04.018
血清高尔基体蛋白73诊断原发性肝癌价值探讨*
The diagnostic value of golgi protein 73 in patients with hepatocellular carcinoma
摘要
Abstract
Objective To evaluate the diagnostic value of golgi protein 73 (GP73) in patients with hepato-cellular carcinoma (HCC). Methods Two hundred hospitalized patients,including 107 cases with HCC,53 cases with cirrhosis and 40 cases with liver failure,and 34 healthy controls were enrolled in this study. Serum GP73 were quantitatively detected by enzyme linked immunosorbent assay. The optimal cut-off value of serum GP73 for HCC diagnosis was determined by the ROC curve and its significance for the diagnosis of HCC was compared with that of serum AFP. Results Serum GP73 in patients with HCC,cirrhosis and liver failure were 123.5±22.35ng/ml,108.9±30.3ng/ml and 130.3±45.6ng/ml,respectively,which were significantly higher than that in healthy controls (44.1±38.9ng/ml,P<0.05);Serum AFP in patients with HCC,cirrhosis and liver failure were 236.6±205.3ng/ml,5.3± 5.56 ng/ml and 53.9 ±40.40 ng/ml,respectively;The optimal cut-off value of serum GP73 for HCC diagnosis was 77.4ng/ml,with a sensitivity of 89.6% and a specificity of 100%;Serum GP73 levels were significantly related to tumor sizes,TNM grades and presence of cirrhosis in HCC patients (P<0.05),but not to age,gender,Edmondson grades and tumor numbers. Conclusions The sensitivity of serum GP73 as a diagnostic tool for HCC is better than AFP,especially in serum AFP-negative patients with HCC.关键词
肝癌/高尔基体蛋白73/诊断Key words
Hepatocellular carcinoma/Golgi protein 73/Diagnosis引用本文复制引用
孔颖,蔺淑梅,王维娟,古艳丽,张曦,叶峰,杨雪亮..血清高尔基体蛋白73诊断原发性肝癌价值探讨*[J].实用肝脏病杂志,2013,(4):341-343,3.基金项目
国家艾滋病和病毒性肝炎等重大传染病防治科技重大专项 （）
