实用肝脏病杂志Issue(6)：620-623,4.DOI:10.3969/.j.issn.1672-5069.2015.06.014
慢性乙型肝炎和乙型肝炎肝硬化患者血清铁蛋白的变化
The change of serum ferritin in patients with hepatitis B and hepatitis B-induced liver cirrhosis
摘要
Abstract
Objective To investigate the correlation of serum ferritin (SF) and liver injuries in patients with chronic hepatitis B and liver cirrhosis after hepatitis B viral infection. Methods SF were detected in 38 patients with chronic hepatitis B,37 with hepatitis B-related liver cirrhosis and in 30 healthy persons,and the relationship between SF and ALT,AST,ALB of liver function,CEA,AFP,Ca125 of tumor markers was analyzed by Spearman rank correlation. Results SF levels in patients with chronic hepatitis B and with liver cirrhosis were (216.79±24.46)μg/l and(220.47±39.38)μg/l,respectively,much higher than in healthy control group[(71.23±4.69)μg/l,P<0.05];There was a significant positive correlation between SF and ALT,AST,GGT,ALP,TBIL,AFP,CA199 and CA50 in patients with chronic hepatitis B,while there was a significant positive correlation between SF and AST,LDH,AFP,CA199,CA724 and CA50 in patients with liver cirrhosis. Conclusions There is a significant correlation between SF and AST,AFP and Ca199 in patients with chronic hepatitis B viral infection-related liver disease. SF may be considered as an important reference index in the diagnosis of liver injury. The overload of iron may enhance the hepatic injury. Detection of SF level is useful in diagnosis,prognosis and treatment in patients with liver diseases.关键词
慢性乙型肝炎/乙型肝炎肝硬化/铁蛋白Key words
Chronic hepatitis B/Liver cirrhosis/Serum ferritin引用本文复制引用
李坤,沈天白,李莹..慢性乙型肝炎和乙型肝炎肝硬化患者血清铁蛋白的变化[J].实用肝脏病杂志,2015,(6):620-623,4.基金项目
上海市卫生局科研课题（项目编号20124041；2014LP084B）；上海市中医药事业发展三年行动计划 （）
