实用医学杂志Issue(20)：3343-3346,4.DOI:10.3969/j.issn.1006-5725.2015.20.018
正常新生儿脑发育的1H-MRS研究
Proton Magnetic Resonance Spectroscopy Study of Normal Neonatal Brain Development
摘要
Abstract
Objective Single voxel proton spectroscopy technique (1H-MRS)was performed in the healthy newborn brain tissue to investigate the metabolic ratio in the right basal ganglia and the right frontal lobe changes with gestational age, and to improve the understanding of the neonatal brain development. Methods In this study, 69 newborns were selected, including twenty-five premature and forty-four term neonates. By using the Gesell developmental scale to evaluate brain development , they all had normal neurologic outcomes at 12-months corrected age. A point-resolved spectroscopy sequence was used to study the metabolic data obtained from each region of interest. Results N-acetylaspartate: creatine and N-acetylaspartate:choline were positively correlated with gestational age (the right basal ganglia r = 0.27, 0.63, the right frontal lobe r = 0.44, 0.64 respectively, P < 0.05) and choline:creatine was negative (the right basal ganglia r = -0.51,the right frontal lobe r = -0.41, P < 0.05), with a linear regression relationship among variables. In the same gestational age group , the N-acetylaspartate: choline of the right basal ganglia was higher than that of the right frontal lobe , and the metabolic ratios among the anatomic locations were significantly different (P < 0.05). Conclusion Neonatal brain metabolite levels are associated with gestational age , and MRS can monitor newborn brain maturation quantitatively.关键词
新生儿/脑/磁共振波谱Key words
Neonate/Brain/Magnetic resonance spectroscopy引用本文复制引用
刘岭岭,孛茹婷,杨文君,李艳,吴玉华,邱颖萍,李鹏,陈志强..正常新生儿脑发育的1H-MRS研究[J].实用医学杂志,2015,(20):3343-3346,4.基金项目
宁夏科技攻关资助项目（编号W2015）；银川市科技攻关资助项目（编号W2015-4）；宁夏医科大学重点项目 （）
