实用医学杂志Issue(20)：3427-3430,4.DOI:10.3969/j.issn.1006-5725.2015.20.047
川南地区维生素D受体FokⅠ多态性与绝经后女性2型糖尿病的相关性
The correlations between vitamin D receptor FokⅠpolymorphism and type 2 diabetes in postmenopausal women
摘要
Abstract
Objective To study the correlations of VDR FokⅠgene polymorphism with type 2 diabetes in postmenopausal women of Han nationality in south Sichuan. Methods 160 patients with type 2 diabetes (T2DM) and 190 healthy cases were enrolled in the study. The VDR FokⅠgene polymorphisms were detected using RFLP-PCR and DNA sequencing. Results The FF, Ff and ff genotype frequencies were 32.5%, 47.5%and 20% in the T2DM group and 15.8%, 53.7%, 30.5% in the control group, respectively (P < 0.05). The allele frequencies were 56.3%, 43.8% in the T2DM group and 42.6%, 57.4% in the control group, respectively (P < 0.05). The risk of T2DM in the FF genotype people was 2.568 times higher than Ff/ff genotype (adjusted OR = 2.568, 95%CI = 1.246 ~ 5.292, P < 0.05). The levels of 2 h PG and HbA1C in the FF genotype people were significantly higher than those of the Ff/ff genotype people (P<0.05). Conclusions There was an association between the VDR FokⅠgene polymorphism and type 2 diabetes incidence in the postmenopausal women in south Sichuan area.关键词
糖尿病,2型/受体,骨化三醇/单核苷酸多态性/绝经后女性Key words
Diabetes, type 2/Receptors, calcitriol/Single nucleotide polymorphism/Postmenopausal women引用本文复制引用
王晓燕,刘鑫,余玥,黄璨,张珑山,刘洪明,邓宇,陈庄,陈枫..川南地区维生素D受体FokⅠ多态性与绝经后女性2型糖尿病的相关性[J].实用医学杂志,2015,(20):3427-3430,4.基金项目
四川省科技厅资助项目（编号14JC01283－LH11）；泸州市科技局资助项目 （）
