无机材料学报Issue(10)：1075-1080,6.DOI:10.15541/jim20150097
聚多巴胺螯合钙离子对钛表面的修饰及修饰后的细胞相容性
Titanium Modification by Calcium Ion Chelated Polydopamine and Its Cytocompatibility
摘要
Abstract
Calcium ions chelation platform was successfully obtained on a titanium surface by modification with polydopamine. The chelation mechanism of polydopamine with Ca2+ was studied. The in vitrobioactivity and cy-tocompatibility of Ca2+ chelation platformwas assessed by incubation in simulated body fluids (SBF) and cultural osteoblast cells (MC3T3-E1), respectively. The results showed that the functional groups of polydopamine chelated Ca2+ were changed from phenolic hydroxyl to benzoquinone. The titanium surface modified by Ca2+-chelated poly-dopamine could induce nucleation and growth of hydroxyapatite in SBF. Meanwhile, Cell attachment and viability assay demonstrated that low concentration of Ca2+ chelation possessed good cytocompatibility.关键词
聚多巴胺/螯合机理/钙离子/生物活性/细胞相容性Key words
polydopamine/chelation mechanism/calcium ion/bioactivity/cytocompatibility分类
通用工业技术引用本文复制引用
谭帼馨,欧阳孔友,周蕾,刘燕,张兰,宁成云..聚多巴胺螯合钙离子对钛表面的修饰及修饰后的细胞相容性[J].无机材料学报,2015,(10):1075-1080,6.基金项目
国家973计划项目(2012CB619100) （2012CB619100）
国家自然科学基金(51372087) （51372087）
广东省科技计划项目(2014A010105048) （2014A010105048）
广东省自然科学基金(2015A030313493) （2015A030313493）
西安交通大学金属材料强度国家重点实验室开放研究项目(20141607) National Basic Research Program of China(2012CB619100) （20141607）
National Natural Science Foundation of China (51372087) （51372087）
Science and Technology Planing Project of Guangdong Province(2014A010105048) （2014A010105048）
Natural Science Foundation of Guangdong Province(2015A030313493) （2015A030313493）
Supported by State Key Laboratory for Mechanical Behavior of Materials(20141607) （20141607）
