武警医学Issue(9)：895-899,5.
以 BMSCs为基础构建组织工程骨修复种植区骨量不足的实验研究
BMSCs-based tissue-engineering bone repairing bone defect in dental implant region:an experimental study
朱彪 1赵刚 2徐红梅 1郭希民 2郭红延1
作者信息
- 1. 100039 北京，武警总医院口腔医学中心
- 2. 100850北京，军事医学科学院基础医学研究所
- 折叠
摘要
Abstract
Objective To repair bone defect in implant region using bone marrow mesenchymal stem cells -based tissue-engi-neering bone and investigate its osteogenesis potential .Methods Bilateral implantaion ,two implants every side , was performed in the mandible premolar region of 3 Beagles and bone defects were created in the distal of every implant .Two bone defects in one side of mandible premolar region were randomly repaired with two types of grafts :PRP (n=6, the control group);and compound osteogenic-induced BMSCs with PRP(n=6, the experimental group).1 and 3 months after transplation, gross investigation,X-ray examination and histological observation were conducted to examine bone formation .Results One month after implantation ,the osteogenesis in ex-perimental group was better than in the control group .We detected more bone matrix and less collagenous fibers in the experimental group.The bone density in the experimental group was higher than in the control group and the difference was significantly different [(101 ±8.99)vs(93 ±9.81),P≤0.05].Three months after implantation,the bone density in the experimental group tended to be higher than in the control group;however,the difference was not statistically significant [(100.75 ±12.05)vs(105 ±11.58)].But we detected more Haversian system in the experimental group .Conclusion Bone marrow stem cell-based tissue-engineered bone has high osteogenic potential around implants .关键词
骨髓间充质干细胞/组织工程骨/口腔种植Key words
bone marrow mesenchymal stem cells/tissue-engineered bones/oral implantology分类
口腔医学引用本文复制引用
朱彪,赵刚,徐红梅,郭希民,郭红延..以 BMSCs为基础构建组织工程骨修复种植区骨量不足的实验研究[J].武警医学,2015,(9):895-899,5.
