西安交通大学学报（医学版）Issue(6)：806-809,4.DOI:10.7652/jdyxb201506018
首发精神分裂症患者治疗前后血清脑源性神经营养因子的变化
Effects of atypical antipsychotics on first-episode antipsychotic-naïve schizophrenia:brain-derived neurotrophic factor study
摘要
Abstract
Objective To evaluate the effects of 6-week atypical antipsychotics treatment on serum brain-derived neurotrophic factor (BDNF)level,and the correlation between BDNF level and clinical efficiency in first-episode antipsychotic-naïve schizophrenia.Methods We recruited 39 hospitalized patients with first-episode antipsychotic-naïve schizophrenia that met with Diagnostic and Statistical Manual of Mental Disorders—4th Edition (DSM-IV).Both Positive and Negative Syndrome Scale (PANSS)and the level of serum BDNF were measured before and after 6 weeks’treatment with atypical antipsychotics.We also studied 30 healthy controls.Serum BDNF was assayed at baseline.Results Pre-treatment BDNF level was significantly lower in the schizophrenic patients than in the controls [(6.82±2.1 5 )μg/L vs .(1 1.6 ± 3.32 )μg/L,t = 7.239,P < 0.001 ].Although BDNF level increased with treatment (t =2.349,P =0.021)in the schizophrenics,post-treatment BDNF level was still lower than in the normal controls (t =4.634,P <0.001).After 6 weeks’treatment for schizophrenia,the total score of PANSS,the scores of positive and negative symptoms,and the score of general psychopathology scale were all decreased (t =6.1 64,P < 0.001;t = 4.520,P < 0.001;t = 4.132,P < 0.001;t = 5.142,P < 0.001 ).Pre-treatment BDNF levels were directly correlated not only with the rate of decreased PANSS total score (r =0.348, P <0.05),but also with the rate of decreased negative symptoms score (r = 0.35 1,P < 0.05 ).However,pre-treatment BDNF levels were not correlated with improved positive symptoms,general psychopathology (r =0.204, 0.186,P >0.05),or duration of illness (r = - 0.058,P > 0.05 ).Changes in BDNF levels with treatment were correlated with the duration of illness (r =-0.345,P <0.05),but not with psychiatric improvement (r =0.036-0.1 74,P >0.05).Conclusion BDNF level is significantly lower in patients with first-episode antipsychotic-naïve schizophrenia than in normal controls.It could be improved by using antipsychotics.Higher pre-treatment BDNF level may predict better response to antipsychotics.关键词
精神分裂症/脑源性神经营养因子/血清Key words
schizophrenia/brain-derived neurotrophic factor (BDNF)/serum分类
医药卫生引用本文复制引用
段惠峰,甘景梨,连亚军,史振娟,高存友,高延伦,张毅..首发精神分裂症患者治疗前后血清脑源性神经营养因子的变化[J].西安交通大学学报（医学版）,2015,(6):806-809,4.基金项目
全军医学科研计划项目(No.CWS12J071) Supported by the Medical Research Program of PLA (No.CWS12J071) （No.CWS12J071）
