陕西科技大学学报（自然科学版）Issue(6)：94-98,115,6.
3-酰胺基喹唑啉酮类化合物合成与环氧合酶-2分子对接抗炎活性预测研究
Synthesis and molecular docking analysis of 3-acylaminoquinazolin-4 (1 H)-ones as potential anti-inflammatory agents
摘要
Abstract
3‐Acylaminoquinazolin‐4 (1 H )‐ones were synthesised by a one‐pot three compo‐nents reaction of isatoic anhydride ,aldehydes and hydrazides in the presence of nano‐CuO in ethanol .The structures of products were characterized by 1 H‐NMR ,13C‐NMR ,IR spectrum . The results of molecular docking showed that all the compounds have potential anti‐inflam‐matory inhibitory activity by Autodock 4 .0 .关键词
3-酰胺基喹唑啉酮类化合物/环氧合酶-2/分子对接/抗炎活性Key words
3-acylaminoquinazolin-4(1 H)-ones/cyclooxygenases-2/molecular docking/anti-inflammatory activity分类
化学引用本文复制引用
张金,刘佳,马养民,任德成,李姣,付方辉..3-酰胺基喹唑啉酮类化合物合成与环氧合酶-2分子对接抗炎活性预测研究[J].陕西科技大学学报（自然科学版）,2015,(6):94-98,115,6.基金项目
陕西省科技厅自然科学基础研究计划项目（2014JQ2064）；陕西科技大学博士科研启动基金项目 （）
