现代妇产科进展Issue(9)：660-664,5.DOI:10.13283/j.cnki.xdfckjz.2015.09.005
S100 A14与RAGE在子宫颈鳞癌组织中的表达及临床意义
The expression and significance of S100 A14 and RAGE in cervical squamous cell carci-noma
杨晶 1王翔宇 1王欣 1郝莉 1崔竹梅1
作者信息
- 1. 青岛大学附属医院妇科，青岛 266071
- 折叠
摘要
Abstract
Objective:To investigate the expression and clinical significance of S100 A14 and the receptor of advanced glycation end products ( RAGE ) in cervical squamous cell carcinoma ( CSCC ) . Methods:Ⅰmmunohistochemical staining was conducted to detect the expression of S100A14 and RAGE in the following tissue samples:23 normal tissue,76 cervical intraepithelial neoplasias ( CⅠN) ,and 102 primary CSCC. Further analysis was made to explore the relationship between the S100 A14 and RAGE expression and various clinicopathological factors. Results:The expressions of S100A14 and RAGE increased during the normal to tumor transition of CSCC ( P<0 . 05 ) , and this increased expression was significantly associated with tumor FⅠGO stage,lymph node metastasis,deep stromal invasion and survival rate (P<0. 05). The expression of RAGE was associated with tumor size but not grade. The expression of S100A14 was associated with grade but not tumor size. There was a significant positive correla-tion between S100 A14 and RAGE in CSCC ( P<0 . 05 ) . Conclusion:S100 A14 and RAGE are both up-regulated expressed in CSCC. The high expression may be responsible for the process of carcinogenesis,progression invasion,and distant metastasis. S100A14 and RAGE may be useful targets for treatment of CSCC and a powerful index to estimate prognosis.关键词
子宫颈肿瘤/S100 A14/RAGE/免疫组织化学Key words
Uterine cervical neoplasms/S100 A14/RAGE/Ⅰmmunohistochemistry分类
医药卫生引用本文复制引用
杨晶,王翔宇,王欣,郝莉,崔竹梅..S100 A14与RAGE在子宫颈鳞癌组织中的表达及临床意义[J].现代妇产科进展,2015,(9):660-664,5.
