现代妇产科进展2015，Vol.24Issue(11)：809-813,5.DOI:10.13283/j.cnki.xdfckjz.2015.11.003
microRNA-106a促进上皮性卵巢癌细胞系迁移和侵袭的研究
microRNA-106 a promotes the migration and invasion of epithelial ovarian cancer cell lines
李敏 1张向宁 2魏媛 1杨春 1董涛涛 1李军1
作者信息
- 1. 山东大学齐鲁医院妇产科,济南 250012
- 2. 山东大学公共卫生学院,济南 250012
- 折叠
摘要
Abstract
Objective:To explore the effects of microRNA-106 a ( miR-106 a ) in the migration and invasion of epithelial ovarian cancer cells,and to verify whether TGFBR2 is the direct target of miR-106a. Methods:The expression of miR-106a in A2780 and Skov-3 cell lines were evaluated and its effects on migration and invasion of EOC cells were determined by transwell assyays in vitro. Finally,the possible target of miR-106a was explored by PicTar and TargetScan algorithm in EOC cells. Results:In this study,miR-106a was highly expressed in metastatic EOC cells (increased by 9 fold,P<0. 05),and could promote the migration and in-vasion of EOC cells in vitro (P<0. 05). Besides,the effects of miR-106a on the promotion of cellular migration and invasion were mediated by TGFBR2 . Conclusion:These observations in-dicate that miR-106 a could accelerate the EOC cell to migrate and invade through the inhibition of the pro-metastatic molecule.关键词
microRNAs/上皮性卵巢癌/迁移/侵袭Key words
MicroRNA-106 a/Epithelial ovarian cancer/Migraion/Invasion分类
医药卫生引用本文复制引用
李敏,张向宁,魏媛,杨春,董涛涛,李军..microRNA-106a促进上皮性卵巢癌细胞系迁移和侵袭的研究[J].现代妇产科进展,2015,24(11):809-813,5.
