中国组织工程研究Issue(2)：223-227,5.DOI:10.3969/j.issn.2095-4344.2013.02.007
自体浓缩骨髓移植促进腱骨愈合★
Condensed autologous bone marrow transplantation facilitates the tendon-bone healing
张义龙 1李宁 2宋有鑫 1方亚群 1张弘 1张金燕1
作者信息
- 1. 承德医学院附属医院骨科，河北省承德市 067000
- 2. 承德医学院附属医院麻醉科，河北省承德市 067000
- 折叠
摘要
Abstract
BACKGROUND:There are a lot of applications of hamstring tendons autografts in the reconstruction of anterior cruciate ligament, which needs a long term for the tendon-bone healing and restricts the early functional activities of patients. OBJECTIVE:To evaluate the effect of condensed autologous bone marrow transplantation on the tendon-bone interface in the reconstruction of anterior cruciate ligament. METHODS:One knee joint was chosen as the experimental group and the other side as the control group in 32 New Zealand rabbits experiencing the reconstruction of anterior cruciate liagment. The tibial tendon-bone interface was injected with condensed autologous bone marrow in the experimental side and the other side was not injected as the control. RESULTS AND CONCLUSION:The histological anatomy showed the tendon-bone interface was fil ed with granulation tissues that were loose, and there were some activities of bone formation in the control group at 2 weeks after operation;the tendon-bone interface was fil ed with granulation tissues that were not compact, but there were active activities of bone formation in the experimental group at 2 weeks after operations. The bound between the tendon and bone was becoming obscure, and there were col agen fiber-fibrocartilage-calcified fibrocartilage-bone transitional zones at the interface in the control group at 12 weeks after operation. In the experimental group, there were conspicuous col agen fiber-fibrocartilage-calcified fibrocartilage-bone transitional zones and clear tidal line at the interface. The maximal pul-out loads in the experimental group were higher than those in the control group at 4, 8 and 12 weeks after operation (P<0.05). These findings indicate that condensed autologous bone marrow transplantation can enhance the tensile strength of tendon-bone interface, and can do good to tendon-bone healing in a bone tunnel.关键词
组织构建/骨组织构建/自体骨髓/移植/交叉韧带/膝关节/腱-骨愈合/组织工程/组织构建图片文章Key words
tissue construction/bone tissue construction/autologous bone marrow/transplantation/cruciate ligament/knee/tendon-bone healing/tissue engineering/tissue construction photographs-containing paper分类
医药卫生引用本文复制引用
张义龙,李宁,宋有鑫,方亚群,张弘,张金燕..自体浓缩骨髓移植促进腱骨愈合★[J].中国组织工程研究,2013,(2):223-227,5.
