中国组织工程研究Issue(2)：337-341,5.DOI:10.3969/j.issn.2095-4344.2013.02.027
Wnt信号通路拮抗剂Dkk1调节骨代谢的最新进展**★◆
Progress in Dickkopf-1-mediated bone metabolism
摘要
Abstract
BACKGROUND:Dickkopf-1 is a soluble inhibitor of canonical Wnt/β-catenin signaling pathway. It blocks Wnt/β-catenin signaling by competitively binding with Wnt protein co-receptor LRP5/6 and then mediates downstream target gene transcription. OBJECTIVE:To review the research progress of Dickkopf-1-mediated bone metabolism, and to provide theoretical foundation of anti-Dickkopf-1 therapy for bone disease. METHODS:A computer-based online search was conducted in Medline and CBM databases from 1995-2012. Articles focusing on Dickkopf-1-mediated bone metabolism were col ected using the keywords of“Dkk1;bone remodeling;bone diseases”in English and Chinese, respectively. High-quality studies were included, while repetitive studies were excluded. RESULTS AND CONCLUSION:118 articles were obtained initial y, and after screening procedure 36 literatures were selectively included in this review final y. Bone tissue is always in dynamic remodeling process. The interaction between osteoblasts and osteoclasts determines the dynamic balance between bone formation and bone resorption. Dickkopf-1 not only inhibits bone formation by blocking Wnt/β-catenin pathway, but also promotes osteoclast differentiation and maturation through the crosstalk with osteoprotegerin/receptor activator of nuclear factor-kappa B ligand/receptor activator of nuclear factor-kappa B axis. Promoting bone formation and inhibiting bone resorption is the biological mechanism of anti-Dickkopf-1 for preventing bone loss which occurs in bone metabolic diseases, and the clinical results are favorable. Therefore, Dickkopf-1 should be a potential target in the treatment of bone disease.关键词
组织构建/组织构建学术探讨/Dkk1/Wnt信号通路/骨重塑/骨疾病/破骨细胞/骨代谢/成骨细胞/骨诱导/骨组织工程/国家自然科学基金Key words
tissue construction/academic discussion in tissue construction/Dickkopf-1/Wnt signaling pathway/bone remodeling/bone diseases/osteoclasts/bone metabolism/osteoblasts/bone induction/bone tissue engineering/National Natural Science Foundation of China分类
医药卫生引用本文复制引用
王露霏,白丁,韩向龙..Wnt信号通路拮抗剂Dkk1调节骨代谢的最新进展**★◆[J].中国组织工程研究,2013,(2):337-341,5.基金项目
国家自然科学基金项目(31000419)；四川省科技厅科技支撑项目(2010SZ0174)。 （31000419）
